Invention Grant
- Patent Title: Geranylgeranyl pyrophosphate synthases
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Application No.: US16345129Application Date: 2017-10-26
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Publication No.: US11225647B2Publication Date: 2022-01-18
- Inventor: Viktor Marius Boer , Priscilla Zwartjens , Johannes Gustaaf Ernst Van Leeuwen
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: McBee Moore & Vanik IP, LLC
- Agent Susan McBee; Chester Moore
- Priority: EP16196095 20161027
- International Application: PCT/EP2017/077439 WO 20171026
- International Announcement: WO2018/078014 WO 20180503
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N9/02 ; C12N9/88 ; C12P15/00 ; C12P19/56 ; C12N15/52 ; C12P7/42

Abstract:
The present invention relates a variant polypeptide having geranylgeranyl pyrophosphate synthase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a geranylgeranyl pyrophosphate synthase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids at positions
92, 100 or 235
said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having geranylgeranyl pyrophosphate synthase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.
92, 100 or 235
said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having geranylgeranyl pyrophosphate synthase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.
Public/Granted literature
- US20190284539A1 GERANYLGERANYL PYROPHOSPHATE SYNTHASES Public/Granted day:2019-09-19
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