Various embodiments provide for calibrating one or more clock signals for a serializer, which can be used with a circuit for data communications, such as serializer/deserializer (SerDes) communications. In particular, for a serializer operating based on a plurality of clock signals, some embodiments provide for calibration of one or more of the plurality of clock signals by adjusting a duty cycle of one or more clock signals, a delay of one or more clock signals, or both.