In one embodiment, a computer system includes a payload sub-system including interfaces to connect with respective devices, transfer data with the respective devices, and receive write transactions from the respective devices, a classifier to classify the received write transactions into payload data and control data, and a payload cache to store the classified payload data, and a processing unit (PU) sub-system including a local PU cache to store the classified control data, wherein the payload cache and the local PU cache are different physical caches in respective different physical locations in the computer system, and processing core circuitry configured to execute software program instructions to perform control and packet processing responsively to the control data stored in the local PU cache.