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公开(公告)号：US11261160B2
公开(公告)日：2022-03-01
申请号：US16467853
申请日：2017-12-06
申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER , Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
IPC分类号： C07D215/233
摘要： The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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![Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof](/abs-image/US/2022/02/01/US11236050B2/abs.jpg.150x150.jpg)
公开(公告)号：US11236050B2
公开(公告)日：2022-02-01
申请号：US16771096
申请日：2018-12-08
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Pavan Kumar Reddy Bandla , Srinivasulu Rangineni
IPC分类号： C07D215/18 , C07D215/48
摘要： The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
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![Solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride and their processes for the preparation thereof](/abs-image/US/2021/10/19/US11149026B2/abs.jpg.150x150.jpg)
公开(公告)号：US11149026B2
公开(公告)日：2021-10-19
申请号：US16645472
申请日：2018-09-07
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkat Reddy Ghojala , Rajeshwar Reddy Sagyam , Srinivasulu Rangineni , Rajashekar Kommera , Markandeya Bekkam
IPC分类号： C07D403/06
摘要： The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2′-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
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![Solid state forms of N-[2-[(I S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methyl sulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-L H-isoindol-4-yl]acetamide and process for preparation thereof](/abs-image/US/2021/02/09/US10913717B2/abs.jpg.150x150.jpg)
公开(公告)号：US10913717B2
公开(公告)日：2021-02-09
申请号：US16706695
申请日：2019-12-07
IPC分类号： C07D209/48 , C07C315/04
摘要： The present invention, relates to solid state forms of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
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公开(公告)号：US11434256B2
公开(公告)日：2022-09-06
申请号：US16965243
申请日：2019-01-25
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Ganapathi Chary Nagunuri
IPC分类号： C07J9/00
摘要： The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3α,7α-dihydroxy6α-ethyl-5β-cholan-24-oic acid which are useful in the preparation of pure 3α,7α-dihydroxy6α-ethyl-5β-cholan-24-oic acid.
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6.发明授权公开(公告)号：US07488729B2
公开(公告)日：2009-02-10
申请号：US10729837
申请日：2003-12-04
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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7.发明授权公开(公告)号：US07790886B2
公开(公告)日：2010-09-07
申请号：US12348360
申请日：2009-01-05
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： C07D409/14
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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8.发明申请POLYMORPHIC FORMS OF ZIPRASIDONEAND ITS HYDROCHLORIDE SALT AND PROCESS FOR PREPARATION THEREOF 失效拉伐沙坦及其盐酸盐的多晶形式及其制备方法公开(公告)号：US20090137605A1
公开(公告)日：2009-05-28
申请号：US12348360
申请日：2009-01-05
申请人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
发明人： Manne Satyanarayana Reddy , Thirumalai Rajan Srinivasan , Venka Bhaskara Rao Uppala , Mummadi Venkatesh , Akundi Surya Prabhakar
IPC分类号： A61K31/497 , C07D409/14
CPC分类号： C07D417/12
摘要： The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
摘要翻译： 本发明涉及齐拉西酮及其盐酸盐和无定形形式的齐拉西酮盐酸盐的结晶形式及其制备方法。 本发明的结晶形式和无定形形式适用于治疗精神病的药物目的。 本发明的方法是简单的，非危险的，商业上合适的。
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