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公开(公告)号：US11261160B2
公开(公告)日：2022-03-01
申请号：US16467853
申请日：2017-12-06
申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER , Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
IPC分类号： C07D215/233
摘要： The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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公开(公告)号：US20210403431A1
公开(公告)日：2021-12-30
申请号：US16467853
申请日：2017-12-06
申请人： THIRUMALAI RAJAN RAJAN Srinivasan , ESWARAIAH Sajja , VENKATA PANAKALA RAO Gogulapati , RAJESHWAR REDDY Sagyam , SHYAM KIRAN BABU Gandham , RAJESHAM Boge , MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
发明人： THIRUMALAI RAJAN SRINIVASAN , ESWARAIAH SAJJA , VENKATA PANAKALA RAO GOGULAPATI , RAJESHWAR REDDY SAGYAM , SHYAM KIRAN BABU GANDHAM , RAJESHAM BOGE
IPC分类号： C07D215/233
摘要： The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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公开(公告)号：US08779161B2
公开(公告)日：2014-07-15
申请号：US13703555
申请日：2011-06-16
申请人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
发明人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
IPC分类号： C07D491/044
CPC分类号： C07D491/04 , C07D491/044
摘要： Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
摘要翻译： 本申请的方面涉及由结构式（I）表示的微晶单斜晶形式的马来酸asenapine; 其准备过程; 及其药学上可接受的剂型。
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公开(公告)号：US20130211099A1
公开(公告)日：2013-08-15
申请号：US13703555
申请日：2011-06-16
申请人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
发明人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , C07D491/044
摘要： Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
摘要翻译： 本申请的方面涉及由结构式（I）表示的微晶单斜晶形式的马来酸asenapine; 其准备过程; 及其药学上可接受的剂型。
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公开(公告)号：US20110213150A1
公开(公告)日：2011-09-01
申请号：US13103277
申请日：2011-05-09
申请人： Srinivas Katkam , Rajeshwar Reddy Sagyam , Vishnuvardhan Sunkara , Sridhar Munagala , Murali Mohan Muttavarapu
发明人： Srinivas Katkam , Rajeshwar Reddy Sagyam , Vishnuvardhan Sunkara , Sridhar Munagala , Murali Mohan Muttavarapu
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Processes for the preparation of palonosetron hydrochloride and its crystalline forms.
摘要翻译： 盐酸帕洛诺司琼及其结晶形式的制备方法。
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公开(公告)号：US07161004B2
公开(公告)日：2007-01-09
申请号：US11157552
申请日：2005-06-21
IPC分类号： C07D239/42 , C07D319/06
CPC分类号： C07D319/06 , C07D239/42
摘要： Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy free radical (TEMPO) as a catalyst.
摘要翻译： 用于制备瑞舒伐他汀的中间体化合物是通过使用次氯酸钠和2,2,6,6-四甲基哌啶氧基自由基（TEMPO）作为催化剂将羟基氧化成醛基的方法制备的。
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