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公开(公告)号：US11261160B2
公开(公告)日：2022-03-01
申请号：US16467853
申请日：2017-12-06
申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER , Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
IPC分类号： C07D215/233
摘要： The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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![Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof](/abs-image/US/2022/02/01/US11236050B2/abs.jpg.150x150.jpg)
公开(公告)号：US11236050B2
公开(公告)日：2022-02-01
申请号：US16771096
申请日：2018-12-08
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Pavan Kumar Reddy Bandla , Srinivasulu Rangineni
IPC分类号： C07D215/18 , C07D215/48
摘要： The present invention relates to novel polymorphs of 4-[3-chloro-4-(N′-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N′-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
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![Solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride and their processes for the preparation thereof](/abs-image/US/2021/10/19/US11149026B2/abs.jpg.150x150.jpg)
公开(公告)号：US11149026B2
公开(公告)日：2021-10-19
申请号：US16645472
申请日：2018-09-07
发明人： Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkat Reddy Ghojala , Rajeshwar Reddy Sagyam , Srinivasulu Rangineni , Rajashekar Kommera , Markandeya Bekkam
IPC分类号： C07D403/06
摘要： The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2′-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
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公开(公告)号：US20130211099A1
公开(公告)日：2013-08-15
申请号：US13703555
申请日：2011-06-16
申请人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
发明人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , C07D491/044
摘要： Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
摘要翻译： 本申请的方面涉及由结构式（I）表示的微晶单斜晶形式的马来酸asenapine; 其准备过程; 及其药学上可接受的剂型。
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公开(公告)号：US08779161B2
公开(公告)日：2014-07-15
申请号：US13703555
申请日：2011-06-16
申请人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
发明人： Srinivas Katkam , Srinivas Polavarapu , Venkata Madhavi Yaddanapudi , Krishna Vinigari , Narasimha Rao Pagadala , Rajeshwar Reddy Sagyam
IPC分类号： C07D491/044
CPC分类号： C07D491/04 , C07D491/044
摘要： Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
摘要翻译： 本申请的方面涉及由结构式（I）表示的微晶单斜晶形式的马来酸asenapine; 其准备过程; 及其药学上可接受的剂型。
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公开(公告)号：US20110213150A1
公开(公告)日：2011-09-01
申请号：US13103277
申请日：2011-05-09
申请人： Srinivas Katkam , Rajeshwar Reddy Sagyam , Vishnuvardhan Sunkara , Sridhar Munagala , Murali Mohan Muttavarapu
发明人： Srinivas Katkam , Rajeshwar Reddy Sagyam , Vishnuvardhan Sunkara , Sridhar Munagala , Murali Mohan Muttavarapu
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： Processes for the preparation of palonosetron hydrochloride and its crystalline forms.
摘要翻译： 盐酸帕洛诺司琼及其结晶形式的制备方法。
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公开(公告)号：US07161004B2
公开(公告)日：2007-01-09
申请号：US11157552
申请日：2005-06-21
IPC分类号： C07D239/42 , C07D319/06
CPC分类号： C07D319/06 , C07D239/42
摘要： Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy free radical (TEMPO) as a catalyst.
摘要翻译： 用于制备瑞舒伐他汀的中间体化合物是通过使用次氯酸钠和2,2,6,6-四甲基哌啶氧基自由基（TEMPO）作为催化剂将羟基氧化成醛基的方法制备的。
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