- 专利标题： Ultra-pure agonists of guanylate cyclase C, method of making and using same
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申请号： US17478027申请日： 2021-09-17
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公开(公告)号： US11319346B2公开(公告)日： 2022-05-03
- 发明人: Kunwar Shailubhai , Stephen Comiskey , Rong Feng , Juncai Bai , Ruoping Zhang , Jun Jia , Junfeng Zhou , Qiao Zhao , Guoqing Zhang
- 申请人： Bausch Health Ireland Limited
- 申请人地址： IE Dublin
- 专利权人： Bausch Health Ireland Limited
- 当前专利权人： Bausch Health Ireland Limited
- 当前专利权人地址： IE Dublin
- 代理机构： Saul Ewing Arnstein & Lehr LLP
- 代理商 Domingos J. Silva; Dennis Ostrovsky
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; C07K7/08 ; C07K1/14 ; C12N9/88 ; B01D15/42
摘要：
The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.
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