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公开(公告)号：US20230116647A1
公开(公告)日：2023-04-13
申请号：US17913843
申请日：2021-03-24
发明人： Maxime Barakat , Howard Franklin , Zeev Heimanson , Thejasvi Ramakrishna , Jason Lamar Vittitow
IPC分类号： A61K31/437 , A61K45/06 , A61K31/4706
摘要： Provided herein are methods for treating COVID-19 or associated GI symptoms with rifaximin compositions.
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公开(公告)号：US20230047106A1
公开(公告)日：2023-02-16
申请号：US17969638
申请日：2022-10-19
发明人： Yunik Chang , Gordon J. Dow , Radhakrishnan Pillai
IPC分类号： A61K31/7056 , A61K31/075 , A61K47/10 , A61K8/02 , A61K8/04 , A61K8/34 , A61K8/55 , A61K8/38 , A61K45/06 , A61Q19/00 , A61K9/00 , A61K31/327 , A61K31/235 , A61K9/14 , A61K47/32
摘要： An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.
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公开(公告)号：US20220380449A1
公开(公告)日：2022-12-01
申请号：US17642130
申请日：2020-09-11
发明人： Robert J. Israel
摘要： The present disclosure is directed to a method of treating nonalcoholic fatty liver disease (NAFLD), and subsets thereof such as nonalcoholic steatohepatitis (NASH), using an IL-17 antagonist, such as a monoclonal antibody that specifically binds to IL-17 receptor A (IL-17RA).
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公开(公告)号：US20220362231A1
公开(公告)日：2022-11-17
申请号：US17561198
申请日：2021-12-23
摘要： Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, and which composition is effective in treating a disorder of the nail or nail bed.
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公开(公告)号：USD959004S1
公开(公告)日：2022-07-26
申请号：US29788730
申请日：2021-07-22
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公开(公告)号：US20220175764A1
公开(公告)日：2022-06-09
申请号：US17529818
申请日：2021-11-18
IPC分类号： A61K31/485 , A61K31/437 , A61P1/16 , A61P1/00
摘要： The present disclosure is directed to the use of methylnaltrexone, or a salt thereof, and rifaximin for the treatment of increased gut permeability, or an associated disorder, e.g., NASH or NAFLD.
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公开(公告)号：US11319346B2
公开(公告)日：2022-05-03
申请号：US17478027
申请日：2021-09-17
发明人： Kunwar Shailubhai , Stephen Comiskey , Rong Feng , Juncai Bai , Ruoping Zhang , Jun Jia , Junfeng Zhou , Qiao Zhao , Guoqing Zhang
摘要： The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.
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公开(公告)号：US11077102B2
公开(公告)日：2021-08-03
申请号：US16280600
申请日：2019-02-20
IPC分类号： A61K31/4745 , A61P17/02 , A61P15/00 , A61P17/00 , A61K9/00 , A61K9/06 , A61K31/437 , A61J1/00 , B65B3/04
摘要： A multidose package containing an imiquimod formulation suitable for treating topical conditions includes: a) a dispensing aperture for dispensing the formulation from the package; b) a reservoir containing sufficient formulation to provide two or more doses; c) a metered dosage element for measuring a predetermined dose of the formulation, the element including an inlet from the reservoir and an outlet to the dispensing aperture; and d) an actuating element operating the dosage element so the predetermined dose is delivered to the dispensing aperture; wherein the dose is dispensed without microbial or other contamination or degradation of the formulation in reservoir. A corresponding course of treatment for various maladies includes providing a multidose package containing an imiquimod formulation suitable for the treatment. A corresponding method of treatment of diseases with multiple doses of an imiquimod formulation includes multiple doses provided by a multidose package.
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公开(公告)号：US10711038B2
公开(公告)日：2020-07-14
申请号：US15471462
申请日：2017-03-28
发明人： Kunwar Shailubhai , Gary S. Jacob
IPC分类号： A61K38/00 , C07K7/08 , A61K47/60 , C07K7/64 , A61K31/192 , A61K31/519 , A61K38/10 , A61K9/00 , A61K9/02 , A61K9/08 , A61K47/02 , A61K45/06 , A61K38/12
摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.
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公开(公告)号：US20200069354A1
公开(公告)日：2020-03-05
申请号：US16556616
申请日：2019-08-30
摘要： Apparatus and methods for delivering coolant to an energy delivery device used to treat tissue with electromagnetic energy. A cooling system includes a pump that is configured to pump a coolant to the energy delivery device.
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