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公开(公告)号：US20220409256A1
公开(公告)日：2022-12-29
申请号：US17835057
申请日：2022-06-08
摘要： Apparatus and methods for delivering coolant to an energy delivery device used to treat tissue with electromagnetic energy. A cooling system includes a pump that is configured to pump a coolant to the energy delivery device.
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公开(公告)号：USD959003S1
公开(公告)日：2022-07-26
申请号：US29780736
申请日：2021-04-26
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公开(公告)号：US11273316B2
公开(公告)日：2022-03-15
申请号：US16556701
申请日：2019-08-30
发明人： Craig Collins , Kurt Duclos , Martin Kenney
摘要： Energy delivery devices with a flexible circuit. The energy delivery devices may be used in the treatment of human tissue, and the flexible circuit move or flex during use. The flexible circuit may include an electronic component and a trace connected with the electronic component. The trace may have a plurality of sections that provide parallel current paths over a portion of the trace. Alternatively, the flexible circuit may include a plurality of traces that are connected with the terminal of the electronic component to provide parallel current paths over their entire length to the terminal of the electronic component. These redundant parallel current paths improve device reliability.
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公开(公告)号：US11142549B2
公开(公告)日：2021-10-12
申请号：US16921450
申请日：2020-07-06
发明人： Kunwar Shailubhai , Stephen Comiskey , Rong Feng , Juncai Bai , Ruoping Zhang , Jun Jia , Junfeng Zhou , Qiao Zhao , Guoqing Zhang
摘要： The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.
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公开(公告)号：USD921212S1
公开(公告)日：2021-06-01
申请号：US29720106
申请日：2020-01-09
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公开(公告)号：US10967043B2
公开(公告)日：2021-04-06
申请号：US16436401
申请日：2019-06-10
IPC分类号： A61K38/00 , A61K38/10 , A61K38/12 , A61K45/06 , A61K38/04 , A61K31/53 , A61K31/192 , A61K31/352 , A61K31/4468 , A61K31/501 , A61K31/519 , A61K31/7004 , A61K9/28 , A61K31/194 , A61K33/42
摘要： This invention provides a method of colonic cleansing.
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公开(公告)号：US10653656B2
公开(公告)日：2020-05-19
申请号：US16108942
申请日：2018-08-22
发明人： Varsha Bhatt , Radhakrishnan Pillai
IPC分类号： A61K31/203 , A61K9/06 , A61K47/32 , A61K47/44 , A61P17/10 , A61K47/14 , A61K47/10 , A61K47/18 , A61K47/36
摘要： In one aspect, topical pharmaceutical compositions for treating a skin condition or disorder are provided. In some embodiments, the topical pharmaceutical composition is formulated as a lotion and comprises a therapeutically effective amount of an active agent; a viscosity increasing agent; a polymeric emulsifier; and an oil component. In some embodiments, the topical pharmaceutical composition comprises tretinoin.
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公开(公告)号：US10597424B2
公开(公告)日：2020-03-24
申请号：US16150703
申请日：2018-10-03
发明人： Kunwar Shailubhai
摘要： This invention provides novel guanylate cyclase C (GC-C) agonists and their therapeutic use. The agonists may be used either alone or in combination with one or more additional agents.
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公开(公告)号：US10421787B2
公开(公告)日：2019-09-24
申请号：US15405787
申请日：2017-01-13
发明人： Juncai Bai , Ruoping Zhang , Jun Jian , Junfeng Zhou , Qiao Zhao , Guoquing Zhang , Kunwar Shailubhai , Stephen Comiskey , Rong Feng
IPC分类号： C07K7/64 , C07K7/08 , C07K14/195
摘要： The invention provides processes of preparing a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-249 described herein.
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公开(公告)号：US11648256B2
公开(公告)日：2023-05-16
申请号：US17993817
申请日：2022-11-23
IPC分类号： A61K31/573 , A61K9/00 , A61K45/06 , A61K9/06 , A61K31/192 , A61K47/26 , A61K9/12 , A61K47/14 , A61K47/44 , A61K9/107 , A61K31/4436
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K9/12 , A61K31/192 , A61K31/4436 , A61K45/06 , A61K47/14 , A61K47/26 , A61K47/44 , A61K31/573 , A61K2300/00 , A61K31/192 , A61K2300/00 , A61K31/4436 , A61K2300/00
摘要： Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.
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