发明授权
- 专利标题： Flourescene energy transfer-based single molecule/ensemble DNA sequencing by synthesis
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申请号： US16091442申请日： 2017-04-04
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公开(公告)号： US11384391B2公开(公告)日： 2022-07-12
- 发明人: Jingyue Ju , Shiv Kumar , James J. Russo , Steffen Jockusch , Zengmin Li , Xiaoxu Li , Sergey M. Kalachikov , Irina Morozova
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 代理商 Gary J. Gershik
- 国际申请： PCT/US2017/025848 WO 20170404
- 国际公布： WO2017/176677 WO 20171012
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H19/10 ; C07H19/20 ; C12Q1/6869
摘要：
This invention provides nucleotide analogues each of which comprises a tag comprising one or more Forster resonance energy transfer (FRET) acceptor fluorophores, a nucleotide polymerase having one or more FRET donor fluorophores, and methods for sequencing single-stranded.
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