Invention Grant
- Patent Title: Capture purification processes for proteins expressed in a non-mammalian system
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Application No.: US16709491Application Date: 2019-12-10
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Publication No.: US11407784B2Publication Date: 2022-08-09
- Inventor: Joseph Edward Shultz , Roger Hart
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Ruggiero, McAllister & McMahon LLC
- Main IPC: C07K1/22
- IPC: C07K1/22 ; C07K1/14 ; C07K1/18 ; C07K1/32 ; C07K16/00
Abstract:
Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of purifying proteins expressed in non-mammalian expression systems in a non-native limited solubility form directly from a refold solution are also disclosed. Resin regeneration methods are also provided.
Information query
