Invention Grant
- Patent Title: Methods of editing DNA methylation
-
Application No.: US16326700Application Date: 2017-08-18
-
Publication No.: US11434476B2Publication Date: 2022-09-06
- Inventor: Rudolf Jaenisch , X Shawn Liu , Hao Wu
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Morse, Barnes-Brown & Pendleton, P.C.
- Agent Lisa M. Warren, Esq.; Erin E. Bryan, Esq.
- International Application: PCT/US2017/047674 WO 20170818
- International Announcement: WO2018/035495 WO 20180222
- Main IPC: C12N9/22
- IPC: C12N9/22 ; A61K35/30 ; A61K35/33 ; C12N9/10 ; C12N15/11 ; C12N15/86 ; C12N15/90 ; A61P3/10 ; A61P9/00 ; A61P9/10 ; A61P9/12 ; A61P11/00 ; A61P25/00 ; A61P25/16 ; A61P25/28 ; A61P35/00 ; A61P37/06 ; A61K38/46 ; C12N15/00 ; C12N15/113 ; A61K31/7088
Abstract:
The invention relates to methods of modifying DNA methylation by contacting a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.
Information query
