- 专利标题： Methods for delivery of biphasic electrical pulses for non-thermal ablation
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申请号： US16535451申请日： 2019-08-08
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公开(公告)号： US11453873B2公开(公告)日： 2022-09-27
- 发明人: Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
- 申请人： Virginia Tech Intellectual Properties, Inc.
- 申请人地址： US VA Blacksburg
- 专利权人： Virginia Tech Intellectual Properties, Inc.
- 当前专利权人： Virginia Tech Intellectual Properties, Inc.
- 当前专利权人地址： US VA Blacksburg
- 代理机构： New River Valley IP Law, P.C.
- 代理商 Michele L. Mayberry
- 主分类号： A61B34/10
- IPC分类号： A61B34/10 ; C12N13/00 ; A61B18/12 ; A61B18/00 ; A61N1/04 ; G16H50/50
摘要：
The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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