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公开(公告)号：US20240008911A1
公开(公告)日：2024-01-11
申请号：US18348605
申请日：2023-07-07
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61N1/327 , C12N13/00 , A61B2018/00446
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US11453873B2
公开(公告)日：2022-09-27
申请号：US16535451
申请日：2019-08-08
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11272979B2
公开(公告)日：2022-03-15
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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公开(公告)号：US20190175260A1
公开(公告)日：2019-06-13
申请号：US16275429
申请日：2019-02-14
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US10245105B2
公开(公告)日：2019-04-02
申请号：US14627046
申请日：2015-02-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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Patent Agency Ranking
公开(公告)号：US20190069945A1
公开(公告)日：2019-03-07
申请号：US16177745
申请日：2018-11-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US20150327944A1
公开(公告)日：2015-11-19
申请号：US14808679
申请日：2015-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
Abstract translation: 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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8.发明申请公开(公告)号：US20140039489A1
公开(公告)日：2014-02-06
申请号：US14017210
申请日：2013-09-03
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61B2018/00446 , A61B2018/00577 , A61B2018/00613 , A61B2034/104 , A61N1/05 , A61N1/327 , C12N13/00
Abstract: A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain.
Abstract translation: 提供了一种用于消融活体哺乳动物的脑组织的方法，包括：将第一和第二电极放置在活的哺乳动物的脑中; 施加多个电脉冲通过所述第一和第二放置的电极，所述电脉冲预定为：引起所述哺乳动物在靶消融区内的脑组织的不可逆电穿孔（IRE）; 并引起围绕目标消融区域的周围区域内的血脑屏障（BBB）的暂时中断，以允许血管中的物质通过暂时中断的BBB转移到周围区域。 这种方法可用于在大脑血管内的BBB上输送大分子物质，其中大分子另外被BBB阻断以通过血管进入大脑。
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公开(公告)号：US12173280B2
公开(公告)日：2024-12-24
申请号：US18120158
申请日：2023-03-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11737810B2
公开(公告)日：2023-08-29
申请号：US17069359
申请日：2020-10-13
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61N1/327 , C12N13/00 , A61B2018/00446 , A61B2018/00577 , A61B2018/00613 , A61B2034/104 , A61N1/05
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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