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公开(公告)号：US12173280B2
公开(公告)日：2024-12-24
申请号：US18120158
申请日：2023-03-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US20150164584A1
公开(公告)日：2015-06-18
申请号：US14627046
申请日：2015-02-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
CPC classification number: A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
Abstract translation: 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 包括用电能处理组织的方法，所述方法包括：使用包括一个或多个电极的一个或多个电穿孔装置将电能传送到组织; 以及冷却组织，周围组织，一个或多个电极或一个或多个电穿孔装置以使加热最小化。 在实施方案中，本发明可用于治疗实体瘤，例如脑肿瘤，并且在一些实施方案中，示例性方法依赖于非热不可逆电穿孔（IRE）以在治疗的肿瘤中引起细胞死亡。
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公开(公告)号：US20230212551A1
公开(公告)日：2023-07-06
申请号：US18120158
申请日：2023-03-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
IPC: A61B18/14
CPC classification number: A61B18/1477 , A61B2018/00577
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US20210186600A1
公开(公告)日：2021-06-24
申请号：US17172731
申请日：2021-02-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US20200093541A9
公开(公告)日：2020-03-26
申请号：US14808679
申请日：2015-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240299076A1
公开(公告)日：2024-09-12
申请号：US18608958
申请日：2024-03-19
Inventor： Timothy J. O'Brien , Robert E. Neal, II , Rafael V. Davalos
CPC classification number: A61B18/1233 , A61B2017/00159 , A61B2017/00172 , A61B2017/0019 , A61B2018/00577 , A61B2018/00613 , A61B2018/00732 , A61B2018/00767 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B18/1477 , A61B2090/0409 , A61N1/327
Abstract: Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.
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公开(公告)号：US11453873B2
公开(公告)日：2022-09-27
申请号：US16535451
申请日：2019-08-08
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US20190175260A1
公开(公告)日：2019-06-13
申请号：US16275429
申请日：2019-02-14
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US10245105B2
公开(公告)日：2019-04-02
申请号：US14627046
申请日：2015-02-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US20150327944A1
公开(公告)日：2015-11-19
申请号：US14808679
申请日：2015-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
Abstract translation: 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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