Invention Grant
- Patent Title: Direct reprogramming of cells to cardiac myocyte fate
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Application No.: US16915225Application Date: 2020-06-29
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Publication No.: US11534464B2Publication Date: 2022-12-27
- Inventor: Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Nutter McClennen & Fish LLP
- Main IPC: A61K35/33
- IPC: A61K35/33 ; A61L27/38 ; A61L27/54 ; A61L29/16 ; A61L31/16 ; C12N15/113 ; C12N5/077
Abstract:
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
Public/Granted literature
- US20200345786A1 DIRECT REPROGRAMMING OF CELLS TO CARDIAC MYOCYTE FATE Public/Granted day:2020-11-05
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