Invention Grant
- Patent Title: Methods for amplification of cell-free DNA using ligated adaptors and universal and inner target-specific primers for multiplexed nested PCR
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Application No.: US16796748Application Date: 2020-02-20
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Publication No.: US11591649B2Publication Date: 2023-02-28
- Inventor: Matthew Rabinowitz , Matthew Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
- Applicant: Natera, Inc.
- Applicant Address: US CA San Carlos
- Assignee: Natera, Inc.
- Current Assignee: Natera, Inc.
- Current Assignee Address: US CA San Carlos
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; G16B10/00 ; C12Q1/6876 ; C12Q1/6844
Abstract:
Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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