Invention Grant
- Patent Title: Rotigotine-containing patch
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Application No.: US16954627Application Date: 2018-12-14
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Publication No.: US11607394B2Publication Date: 2023-03-21
- Inventor: Hiroyuki Araki , Yuka Takagi , Yoko Fujiwara , Hiroaki Kobayashi , Takao Kurokawa
- Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
- Applicant Address: JP Tosu
- Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
- Current Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
- Current Assignee Address: JP Tosu
- Agency: Sughrue Mion, PLLC
- Priority: JPJP2017-242845 20171219,JPJP2018-143868 20180731
- International Application: PCT/JP2018/046137 WO 20181214
- International Announcement: WO2019/124261 WO 20190627
- Main IPC: A61P25/16
- IPC: A61P25/16 ; A61K47/32 ; A61K31/381 ; A61K9/70

Abstract:
The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.
Public/Granted literature
- US20200306203A1 ROTIGOTINE-CONTAINING PATCH Public/Granted day:2020-10-01
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