- 专利标题： Nipah virus envelope glycoprotein pseudotyped lentivirus
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申请号： US16094636申请日： 2017-04-20
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公开(公告)号： US11608509B2公开(公告)日： 2023-03-21
- 发明人: Caroline Costa Fejoz , Els Verhoeyen , François-Loïc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
- 申请人： Ecole Normale Superieure de Lyon , Centre National de la Recherche Scientifique (CNRS) , Université Claude Bernard Lyon 1 , Institut National de la Sante et de la Recherche Medicale (INSERM)
- 申请人地址： FR Lyons; FR Paris; FR Villeurbanne; FR Paris
- 专利权人： Ecole Normale Superieure de Lyon,Centre National de la Recherche Scientifique (CNRS),Université Claude Bernard Lyon 1,Institut National de la Sante et de la Recherche Medicale (INSERM)
- 当前专利权人： Ecole Normale Superieure de Lyon,Centre National de la Recherche Scientifique (CNRS),Université Claude Bernard Lyon 1,Institut National de la Sante et de la Recherche Medicale (INSERM)
- 当前专利权人地址： FR Lyons; FR Paris; FR Villeurbanne; FR Paris
- 代理机构： Morrison & Foerster LLP
- 优先权： EP16305468 20160421
- 国际申请： PCT/EP2017/059435 WO 20170420
- 国际公布： WO2017/182585 WO 20171026
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; A61P35/00 ; C07K14/005 ; C07K14/54 ; C07K16/28 ; C07K16/32 ; A61K39/00
摘要：
The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
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