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公开(公告)号：US11608509B2
公开(公告)日：2023-03-21
申请号：US16094636
申请日：2017-04-20
申请人： Ecole Normale Superieure de Lyon , Centre National de la Recherche Scientifique (CNRS) , Université Claude Bernard Lyon 1 , Institut National de la Sante et de la Recherche Medicale (INSERM)
发明人： Caroline Costa Fejoz , Els Verhoeyen , François-Loïc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
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公开(公告)号：US20190144885A1
公开(公告)日：2019-05-16
申请号：US16094636
申请日：2017-04-20
申请人： Ecole Normale Superieure de Lyon , Centre National de la Recherche Scientifique (CNRS , Université Claude Bernard Lyon 1 , Institut National de la Sante et de la Recherche Medicale (INSERM)
发明人： Caroline Costa Fejoz , Els Verhoeyen , François-Loïc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
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