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公开(公告)号：US11608509B2
公开(公告)日：2023-03-21
申请号：US16094636
申请日：2017-04-20
申请人： Ecole Normale Superieure de Lyon , Centre National de la Recherche Scientifique (CNRS) , Université Claude Bernard Lyon 1 , Institut National de la Sante et de la Recherche Medicale (INSERM)
发明人： Caroline Costa Fejoz , Els Verhoeyen , François-Loïc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
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公开(公告)号：US20190144885A1
公开(公告)日：2019-05-16
申请号：US16094636
申请日：2017-04-20
申请人： Ecole Normale Superieure de Lyon , Centre National de la Recherche Scientifique (CNRS , Université Claude Bernard Lyon 1 , Institut National de la Sante et de la Recherche Medicale (INSERM)
发明人： Caroline Costa Fejoz , Els Verhoeyen , François-Loïc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
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公开(公告)号：US11623950B2
公开(公告)日：2023-04-11
申请号：US15742909
申请日：2016-07-08
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE NORMALE SUPERIEURE DE LYON
IPC分类号： C07K16/00 , C07K16/46 , C12N15/62 , C12N15/86 , A61K48/00 , C07K16/10 , A61K39/29 , A61P37/02 , A61P31/00 , A61P35/00 , C12N15/113 , C12N15/85 , A61K39/00
摘要： The invention concerns a multicistronic nucleic acid, in particular an isolated multicistronic nucleic acid, comprising: A) a sequence comprising successively: A1) a sequence encoding the light chain variable domain of an antibody of interest, fused in the frame with A2) a sequence encoding the constant region of the light chain of an immunoglobulin Ig; and B) a sequence comprising successively: B1) a sequence encoding the heavy chain variable domain of said antibody of interest, fused in the frame with B2) a sequence encoding the constant regions of the heavy chain of an immunoglobulin Ig′ in secretory form; B3) an intronic sequence of the gene of the heavy chain of said immunoglobulin Ig′, said intronic sequence comprising an internal 5′ splice site enabling the splicing of said intronic sequence B3) and a secretory-specific poly(A) (p AS) signal from the 3′ terminal exon of said gene; B4) a sequence, in frame with sequence B1), encoding the transmembrane and cytoplasmic domains M1 and M2 of the immunoglobulin Ig′ BCR, wherein said sequence B4) comprises, between the coding sequences of the M1 and M2 domains, an intronic sequence containing a splice site enabling the splicing of said intronic sequence between the M1 and M2 domains coding sequences; and B5) a membrane-anchored specific poly(A) signal (p AM), after the stop codon of the M2 domain, wherein the multicistronic nucleic acid enables the co-expression of the sequences A and B into separate proteins.
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公开(公告)号：US20140017792A1
公开(公告)日：2014-01-16
申请号：US13913815
申请日：2013-06-10
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K2319/02 , C07K2319/42 , C12N2740/16043 , C12N2740/16045 , C12N2810/6045 , C12N2810/852
摘要： The present invention relates to a vector particle for transferring biological material into cells, wherein said vector particle comprises at least: a first protein which comprises the transmembrane and extracellular domains of the feline endogenous RD114 virus envelope glycoprotein, and a second protein which comprises a ligand of the c-Kit receptor.
摘要翻译： 本发明涉及用于将生物材料转移到细胞中的载体颗粒，其中所述载体颗粒至少包含：包含猫内源性RD114病毒包膜糖蛋白的跨膜和细胞外结构域的第一种蛋白质，以及包含配体 的c-Kit受体。
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公开(公告)号：US09714434B2
公开(公告)日：2017-07-25
申请号：US13913815
申请日：2013-06-10
CPC分类号： C12N15/86 , A61K48/00 , C07K2319/02 , C07K2319/42 , C12N2740/16043 , C12N2740/16045 , C12N2810/6045 , C12N2810/852
摘要： The present invention relates to a vector particle for transferring biological material into cells, wherein said vector particle comprises at least: a first protein which comprises the transmembrane and extracellular domains of the feline endogenous RD114 virus envelope glycoprotein, and a second protein which comprises a ligand of the c-Kit receptor.
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公开(公告)号：US20140235700A1
公开(公告)日：2014-08-21
申请号：US14346357
申请日：2012-09-28
申请人： ECOLE NORMALE SUPERIEURE DE LYON , INSTITUT NATIONAL DELA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2740/13022 , C12N2740/15043 , C12N2740/15045 , C12N2740/16043 , C12N2740/16045 , C12N2810/6054
摘要： The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide.
摘要翻译： 本发明涉及用于将生物材料转移到细胞中的假型病毒载体颗粒，其中所述载体颗粒至少包含： - 嵌合包膜糖蛋白，其包含或组成狒狒内源性逆转录病毒（BaEV）的跨膜和细胞外结构域的融合体， 包膜糖蛋白和鼠白血病病毒（MLV）包膜糖蛋白的胞质尾区; 或 - 修饰的BaEV包膜糖蛋白，其中细胞质尾结构域缺乏融合抑制性R肽。
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