Invention Grant
- Patent Title: Affinity purification of glycosidase-cleaving enzymes
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Application No.: US16978417Application Date: 2019-03-05
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Publication No.: US11685912B2Publication Date: 2023-06-27
- Inventor: Brian Dwyer , Bohong Zhang , Jun Hu , Muthuraman Meiyappan , Thomas Miller , Paul McLean , Clark Pan
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka
- Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee Address: JP Osaka
- Agency: Troutman Pepper Hamilton Sanders LLP
- International Application: PCT/US2019/020690 2019.03.05
- International Announcement: WO2019/173293A 2019.09.12
- Date entered country: 2020-09-04
- Main IPC: C12N9/40
- IPC: C12N9/40 ; B01J20/286 ; B01J20/289 ; B01J20/32
Abstract:
The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.
Public/Granted literature
- US20210040465A1 AFFINITY PURIFICATION OF GLYCOSIDE-CLEAVING ENZYMES Public/Granted day:2021-02-11
Information query
IPC分类:
