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    Peptoid affinity ligands
    3.
    发明授权
    Peptoid affinity ligands 有权

    公开(公告)号：US11053282B2

    公开(公告)日：2021-07-06

    申请号：US16083366

    申请日：2017-03-09

    申请人： MIKE-ANN, LLC

    发明人： Andrew J. Murphy ,  Tee Bordelon ,  Michael Crapanzano

    IPC分类号： C07K7/06 ,  C07K5/083 ,  B01D15/38 ,  B01J20/26 ,  C07K1/22 ,  B01J20/289 ,  B01J20/32 ,  C07K16/00 ,  C07K5/103 ,  C07K7/02 ,  C07K5/11

    摘要： Disclosed herein are peptoids and related compounds, including peptoid affinity ligands, and hybrid peptoids, for binding and/or purifying immunoglobulins, immunoglobulin fragments or immunoglobulin fusion proteins thereof. Methods of making peptoid affinity ligands and using the same to bind, purify and/or isolate immunoglobulins and related compounds are also disclosed. Such peptoid affinity ligands comprise a peptoid compound consisting of sequentially coupled peptoid residues forming a peptoid backbone, with one or more functional groups appended to a Nitrogen of the peptoid residues of the peptoid backbone configured to provide the desired binding affinity. The peptoids can further comprise a peptoid backbone with at least one functional group coupled to an alpha carbon (C) of a peptide bond in the peptoid backbone thereby forming a hybrid peptoid.

    Functionalized support for analytical sample preparation
    6.
    发明授权
    Functionalized support for analytical sample preparation 有权

    公开(公告)号：US10436684B2

    公开(公告)日：2019-10-08

    申请号：US15269647

    申请日：2016-09-19

    申请人： Agilent Technologies, Inc.

    发明人： Bruce Richter ,  Derick Lucas ,  David Long ,  Limian Zhao

    IPC分类号： G01N1/00 ,  G01N1/40 ,  B01D15/38 ,  B01J20/22 ,  B01J20/28 ,  B01J20/289 ,  G01N30/72 ,  G01N30/84

    摘要： Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an α-cyclodextrin moiety. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes contacting a sample comprising a matrix-interfering agent and an analyte with α-cyclodextrin modified particles to produce a contacted sample wherein the matrix-interfering agent binds to the α-cyclodextrin modified particles; separating the α-cyclodextrin modified particles from the contacted sample to produce a matrix-reduced composition; and detecting the analyte in the matrix-reduced composition. Systems for practicing the subject methods are provided that include the subject solid phase sorbent.