A semiconductor memory device includes a substrate having a first active pattern including first and second source/drain regions, a gate electrode intersecting the first active pattern and disposed between the first and second source/drain regions, a bit line intersecting the first active pattern and electrically connected to the first source/drain region, a spacer disposed on a sidewall of the bit line, a contact electrically connected to the second source/drain region and spaced apart from the bit line with the spacer interposed therebetween, an interface layer disposed between the second source/drain region and the contact, and forming an ohmic contact between the second source/drain region and the contact, and a data storage element disposed on the contact. A bottom of the contact is lower than a top surface of the substrate. The contact is formed of a metal, a conductive metal nitride, and/or a combination thereof.