发明授权
- 专利标题： Methods and systems for functional maturation of iPSC and ESC derived cardiomyocytes
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申请号： US16490302申请日： 2018-03-03
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公开(公告)号： US11746328B2公开(公告)日： 2023-09-05
- 发明人: Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
- 申请人： Agilent Technologies, Inc.
- 申请人地址： US CA Santa Clara
- 专利权人： Agilent Technologies, Inc.
- 当前专利权人： Agilent Technologies, Inc.
- 当前专利权人地址： US CA Santa Clara
- 国际申请： PCT/US2018/020817 2018.03.03
- 国际公布： WO2018/161063A 2018.09.07
- 进入国家日期： 2019-08-30
- 主分类号： C12N5/077
- IPC分类号： C12N5/077 ; C12N5/00 ; C12N5/074 ; C12N13/00 ; G01N27/02
摘要：
Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that induces maturation until the immature cardiomyocytes mature into functionally adult cardiomyocytes.
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