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公开(公告)号：US20240076619A1
公开(公告)日：2024-03-07
申请号：US18361584
申请日：2023-07-28
Applicant: Agilent Technologies, Inc.
Inventor： Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
CPC classification number: C12N5/0657 , C12N5/0018 , C12N5/0696 , C12N13/00 , G01N27/028 , C12N2506/45 , C12N2529/00
Abstract: A method of characterizing an effect of a compound on cardiomyocyte beating, including providing a system configured to culture, electrically pace, and monitor heating of beating cells: culturing two populations of immature cardiomyocytes in the system; adding a compound suspected of having an effect on cardiomyocyte maturation to one of the populations of immature cardiomyocytes; electrically pacing the two populations of immature cardiomyocytes according to a pulse profile that functionally matures immature cardiomyocytes until at least one of the two populations of cardiomyocytes is functionally mature; and Characterizing the compound as further driving maturation if the population with compound addition functionally matures before the other cardiomyocyte population.
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公开(公告)号：USD941488S1
公开(公告)日：2022-01-18
申请号：US29723537
申请日：2020-02-07
Applicant: Agilent Technologies, Inc.
Designer： Longbin Fang , Qiting Ye , Xin Yao , Zhi Tao , Jian Wu , Nan Li , Xiaobo Wang
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公开(公告)号：US11346797B2
公开(公告)日：2022-05-31
申请号：US16721742
申请日：2019-12-19
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Wei Ouyang , Nan Li , Tianxing Wang , Xiaoyu Zhang , Xiao Xu , Yama A. Abassi
IPC: G01N27/02 , G01N33/483
Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.
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公开(公告)号：US20210041418A1
公开(公告)日：2021-02-11
申请号：US17083589
申请日：2020-10-29
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Nan Li , Lincoln Muir , Xiao Xu
IPC: G01N33/50 , G01N33/543 , G01N27/02
Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.
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公开(公告)号：US20250034506A1
公开(公告)日：2025-01-30
申请号：US18787832
申请日：2024-07-29
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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Patent Agency Ranking
公开(公告)号：US11287379B2
公开(公告)日：2022-03-29
申请号：US16833235
申请日：2020-03-27
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Jian Wu , Ye Chen , Tianxing Wang , Xiaobo Wang
Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.
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公开(公告)号：US20210301245A1
公开(公告)日：2021-09-30
申请号：US16833651
申请日：2020-03-29
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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公开(公告)号：US12066428B2
公开(公告)日：2024-08-20
申请号：US17083589
申请日：2020-10-29
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Nan Li , Lincoln Muir , Xiao Xu
CPC classification number: G01N33/5011 , C12N1/06 , C12N5/0693 , C12N7/00 , G01N27/021 , G01N33/5047 , C12N1/38
Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.
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公开(公告)号：US12049615B2
公开(公告)日：2024-07-30
申请号：US18194277
申请日：2023-03-31
Applicant: Agilent Technologies, Inc.
Inventor： Nan Li , Xin Yao , Longbin Fang , Lingbo Kong , Qiting Ye , Caixia Yang , Brandon Lamarche , Xiaobo Wang
CPC classification number: C12M41/06 , C12M23/12 , C12M31/02 , C12M41/36 , C12M41/48 , G01N21/6428 , G01N33/5005 , G01N2021/6439
Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.
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公开(公告)号：US11746328B2
公开(公告)日：2023-09-05
申请号：US16490302
申请日：2018-03-03
Applicant: Agilent Technologies, Inc.
Inventor： Xiaoyu Zhang , Yama A. Abassi , Nan Li , Xiaobo Wang
CPC classification number: C12N5/0657 , C12N5/0018 , C12N5/0696 , C12N13/00 , G01N27/028 , C12N2506/45 , C12N2529/00
Abstract: Methods of inducing functional maturation of immature cardiomyocytes derived from induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) by electrically pacing the immature cardiomyocytes according to a pulse profile that induces maturation until the immature cardiomyocytes mature into functionally adult cardiomyocytes.
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