Disclosed are techniques for muting positioning reference signals. In aspects, a location server sends, to a user equipment (UE), a plurality of positioning reference signal configurations and one or more positioning reference signal muting configurations associated with a transmission-reception point (TRP) identifier (ID) and/or a positioning reference signal ID. A first TRP sends, to the UE, a command triggering at least one positioning reference signal muting configuration, wherein the triggered positioning reference signal muting configuration indicates that: the one or more positioning reference signals of the one or more positioning reference signal occasions of at least one positioning reference signal configuration are not being transmitted, or the one or more positioning reference signals of the one or more positioning reference signal occasions of all of the plurality of positioning reference signal configurations are not being transmitted, and mutes positioning reference signals according to the triggered positioning reference signal muting configurations.