Invention Grant
- Patent Title: Agent for restoring visual function or agent for preventing deterioration in visual function
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Application No.: US16329631Application Date: 2017-09-01
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Publication No.: US11932679B2Publication Date: 2024-03-19
- Inventor: Toshihide Kurihara , Yusaku Katada , Hiromitsu Kunimi , Kazuo Tsubota , Hideki Kandori
- Applicant: KEIO UNIVERSITY , NAGOYA INSTITUTE OF TECHNOLOGY
- Applicant Address: JP Tokyo
- Assignee: Keio University,Nagoya Institute of Technology
- Current Assignee: Keio University,Nagoya Institute of Technology
- Current Assignee Address: JP Tokyo; JP Nagoya
- Agency: HALEY GUILIANO LLP
- Agent James F. Haley, Jr.
- Priority: JP 16172149 2016.09.02
- International Application: PCT/JP2017/031579 2017.09.01
- International Announcement: WO2018/043707A 2018.03.08
- Date entered country: 2019-02-28
- Main IPC: C07K14/72
- IPC: C07K14/72 ; A61K31/7088 ; A61K35/76 ; A61K38/00 ; A61K48/00 ; A61P27/02 ; C07K14/195 ; C07K14/705 ; C07K19/00 ; C12N15/09 ; C12N15/86

Abstract:
The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
Public/Granted literature
- US20190194294A1 AGENT FOR RESTORING VISUAL FUNCTION OR AGENT FOR PREVENTING DETERIORATION IN VISUAL FUNCTION Public/Granted day:2019-06-27
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