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1.发明公开公开(公告)号：US20240247049A1
公开(公告)日：2024-07-25
申请号：US18443512
申请日：2024-02-16
IPC分类号： C07K14/72 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C07K14/705 , C07K19/00 , C12N15/09 , C12N15/86
CPC分类号： C07K14/723 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C12N15/09 , C12N15/86 , C07K14/705 , C07K19/00 , C12N2750/14143
摘要： The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
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2.发明申请公开(公告)号：US20190194294A1
公开(公告)日：2019-06-27
申请号：US16329631
申请日：2017-09-01
IPC分类号： C07K14/72 , C07K14/195 , A61P27/02 , C12N15/86
CPC分类号： C07K14/723 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C07K14/705 , C07K19/00 , C12N15/09 , C12N15/86 , C12N2750/14143
摘要： The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
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3.发明授权公开(公告)号：US11932679B2
公开(公告)日：2024-03-19
申请号：US16329631
申请日：2017-09-01
IPC分类号： C07K14/72 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C07K14/705 , C07K19/00 , C12N15/09 , C12N15/86
CPC分类号： C07K14/723 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C12N15/09 , C12N15/86 , C07K14/705 , C07K19/00 , C12N2750/14143
摘要： The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
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