The disclosed embodiments are generally directed to inline encryption of data at line speed at a chip interposed between two memory components. The inline encryption may be implemented at a System-on-Chip (“SOC” or “SOC”). The memory components may comprise Non-Volatile Memory express (NVMe) and a dynamic random access memory (DRAM). An exemplary device includes an SOC to communicate with a Non-Volatile Memory NVMe circuitry to provide direct memory access (DMA) to an external memory component. The SOC may include: a cryptographic controller circuitry; a cryptographic memory circuitry in communication with the cryptographic controller, the cryptographic memory circuitry configured to store instructions to encrypt or decrypt data transmitted through the SOC; and an encryption engine in communication with the crypto controller circuitry, the encryption engine configured to encrypt or decrypt data according to instructions stored at the crypto memory circuitry. Other embodiments are also disclosed and claimed.