Methods, systems, and devices for message signaled interrupt (MSI-X) tunneling on a host device exposed by a bridge connection are described. A device may receive data and a first interrupt signal from a remote destination over a network protocol. The device may receive the data and/or the first interrupt signal over the bridge connection, via a tunneled communication from the remote destination. The device may generate a second interrupt signal based on the first interrupt signal and a local interrupt configuration provided by a system bus driver of the device. The device may inject the data and the second interrupt signal over the system bus. Injecting the data and injecting the second interrupt signal may include ensuring the data is made available to the system bus driver, prior to the interrupt handler receiving the second interrupt signal.