发明申请
- 专利标题: Novel autoinducer molecules and uses therefor
- 专利标题(中): 新型自体诱导分子及其用途
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申请号: US10844037申请日: 2004-09-16
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公开(公告)号: US20050009869A1公开(公告)日: 2005-01-13
- 发明人: Everett Pesci , Barbara Iglewski , Jared Milbank , James Pearson , Andrew Kende , Everett Greenberg
- 申请人: Everett Pesci , Barbara Iglewski , Jared Milbank , James Pearson , Andrew Kende , Everett Greenberg
- 主分类号: C07D215/22
- IPC分类号: C07D215/22 ; C07D215/233 ; C12N1/20 ; C12P17/12 ; C12Q1/02 ; C12Q1/04 ; C07D215/16 ; C07D311/74 ; C07D335/06
摘要:
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signalling in bacteria using the compounds of the invention are also described.
公开/授权文献
- US07442798B2 Autoinducer molecules and uses therefor 公开/授权日:2008-10-28