发明申请
US20050042680A1 Single chain antigen-binding polypeptides for polymer conjugation
审中-公开
用于聚合物缀合的单链抗原结合多肽
- 专利标题： Single chain antigen-binding polypeptides for polymer conjugation
- 专利标题（中）： 用于聚合物缀合的单链抗原结合多肽
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申请号： US10831063申请日： 2004-04-23
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公开(公告)号： US20050042680A1公开(公告)日： 2005-02-24
- 发明人: David Filpula , Karen Yang , Amartya Basu , Maoliang Wang
- 申请人： David Filpula , Karen Yang , Amartya Basu , Maoliang Wang
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K39/38 ; A61K47/48 ; A61P35/00 ; C07H21/04 ; C07K14/00 ; C07K14/715 ; C07K16/00 ; C07K16/30 ; C07K16/44 ; C07K19/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12P21/02 ; C12P21/08 ; C12R1/84 ; G01N33/68
摘要：
The present invention relates to monovalent and multivalent single-chain antigen-binding polypeptides with site-specific modifications. The provided polypeptides are capable of being covalently linked or conjugated to polyalkylene oxides at the modified sites. The resulting conjugates retain antigen binding properties and exhibit prolonged circulating time and reduced antigenicity relative to unconjugated single chain antigen binding polypeptides. Methods and compositions for making and using the single chain antigen-binding polypeptides with site-specific modifications are also provided.