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公开(公告)号：US20050042680A1
公开(公告)日：2005-02-24
申请号：US10831063
申请日：2004-04-23
申请人： David Filpula , Karen Yang , Amartya Basu , Maoliang Wang
发明人： David Filpula , Karen Yang , Amartya Basu , Maoliang Wang
IPC分类号： G01N33/53 , A61K39/38 , A61K47/48 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/715 , C07K16/00 , C07K16/30 , C07K16/44 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/84 , G01N33/68
CPC分类号： G01N33/6857 , A61K47/60 , A61K2039/505 , C07K16/30 , C07K19/00 , C07K2317/41 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to monovalent and multivalent single-chain antigen-binding polypeptides with site-specific modifications. The provided polypeptides are capable of being covalently linked or conjugated to polyalkylene oxides at the modified sites. The resulting conjugates retain antigen binding properties and exhibit prolonged circulating time and reduced antigenicity relative to unconjugated single chain antigen binding polypeptides. Methods and compositions for making and using the single chain antigen-binding polypeptides with site-specific modifications are also provided.
摘要翻译： 本发明涉及具有位点特异性修饰的单价和多价单链抗原结合多肽。 所提供的多肽能够在修饰部位共价连接或与聚环氧烷共轭。 所得到的缀合物保留抗原结合性质并且相对于未缀合的单链抗原结合多肽显示延长的循环时间和降低的抗原性。 还提供了用于制备和使用具有位点特异性修饰的单链抗原结合多肽的方法和组合物。
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公开(公告)号：US20090214472A1
公开(公告)日：2009-08-27
申请号：US10590421
申请日：2005-02-28
申请人： David Ray Filpula , Karen Yang , Amartya Basu , Maoliang Wang
发明人： David Ray Filpula , Karen Yang , Amartya Basu , Maoliang Wang
CPC分类号： A61K38/215 , A61K47/60 , C07K16/249
摘要： Biologically-active, interferon-beta 1b-polymer conjugate compositions are disclosed. The polymer portion is preferably a polyalkylene oxide polymer having a molecular weight of at least about 12 kDa. Methods of making and using the same are also disclosed.
摘要翻译： 公开了生物活性的，干扰素-β1b-聚合物共轭物组合物。 聚合物部分优选为具有至少约12kDa分子量的聚环氧烷聚合物。 还公开了制备和使用它们的方法。
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公开(公告)号：US20080125363A1
公开(公告)日：2008-05-29
申请号：US11793165
申请日：2005-12-14
申请人： David Ray Filpula , Karen Yang , Amartya Basu , Ira H. Pastan
发明人： David Ray Filpula , Karen Yang , Amartya Basu , Ira H. Pastan
摘要： The present invention relates to polymer conjugates of SS1P, and methods of making using the same.
摘要翻译： 本发明涉及SS1P的聚合物共轭物及其制备方法。
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公开(公告)号：US20100104259A1
公开(公告)日：2010-04-29
申请号：US12259849
申请日：2008-10-28
IPC分类号： H04N5/91
CPC分类号： H04N5/913
摘要： Subject matter disclosed herein relates to a method of detecting video content, and in particular, to a method of defining one or more digital fingerprints to identify video content.
摘要翻译： 本文公开的主题涉及一种检测视频内容的方法，特别涉及一种定义一个或多个数字指纹以识别视频内容的方法。
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公开(公告)号：US08835183B2
公开(公告)日：2014-09-16
申请号：US12350090
申请日：2009-01-07
申请人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
发明人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
IPC分类号： G01N33/543 , G01N33/68 , G01N33/566
CPC分类号： G01N33/689 , G01N33/543 , G01N33/566 , G01N33/6872 , G01N2333/475 , G01N2333/515 , G01N2333/71 , G01N2333/91205 , G01N2800/368 , G01N2800/50 , G01N2800/56
摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.
摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。
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公开(公告)号：US08433175B2
公开(公告)日：2013-04-30
申请号：US12259849
申请日：2008-10-28
IPC分类号： H04N9/80
CPC分类号： H04N5/913
摘要： Disclosed is a method comprising identifying one or more moving features in a first video via a computing platform, representing the one or more moving features as fingerprint representations via the computing platform, and comparing the fingerprint representations with fingerprint representations of a second video to determine a match via the computing platform.
摘要翻译： 公开了一种方法，包括经由计算平台将第一视频中的一个或多个移动特征识别，经由计算平台将一个或多个移动特征表示为指纹表示，以及将指纹表示与第二视频的指纹表示进行比较，以确定 通过计算平台进行匹配。
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公开(公告)号：US20090176247A1
公开(公告)日：2009-07-09
申请号：US12350090
申请日：2009-01-07
申请人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
发明人： George Bashirians , Deborah Byrne , Sarah Groulx , Sharon Jackson , Heather Lane-Brown , Banumathi Sankaran , Edward Scalice , Karen Yang , Jian Zheng
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/689 , G01N33/543 , G01N33/566 , G01N33/6872 , G01N2333/475 , G01N2333/515 , G01N2333/71 , G01N2333/91205 , G01N2800/368 , G01N2800/50 , G01N2800/56
摘要： Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.
摘要翻译： 提供了确定包含第一和第二分子实体的复合物的存在或量的方法，优选为sFlt-1：PlGF复合物。 复合物的存在或量的确定可用于预测，检测，监测疾病或指导治疗相关疾病如血管，血管相关疾病，心脏，心脏相关疾病，癌症， 癌症相关疾病，先兆子痫和先兆子痫相关疾病。 测定sFlt-1：血管生成因子复合物特别可用于预测和检测妊娠早期阶段和疾病阶段的先兆子痫，其临床评估可能是不知情的。
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