发明申请
- 专利标题： EP4 receptor antagonists
- 专利标题（中）： EP4受体拮抗剂
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申请号： US10964831申请日： 2004-10-15
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公开(公告)号： US20050124676A1公开(公告)日： 2005-06-09
- 发明人: David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
- 申请人： David Clark , Neil Harris , Garry Fenton , George Hynd , Keith Stuttle , Jonathan Sutton , Alexander Oxford , Richard Davis , Robert Coleman , Kenneth Clark
- 优先权： GB0324269.0 20031016
- 主分类号： A61K31/34
- IPC分类号： A61K31/34 ; A61K31/41 ; C07D307/68 ; C07D45/02
摘要：
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
公开/授权文献
- US07417068B2 EP4 receptor antagonists 公开/授权日：2008-08-26
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