公开(公告)号：US20080039502A1

公开(公告)日：2008-02-14

申请号：US11889570

申请日：2007-08-14

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  A61P25/06 ,  C07D231/12 ,  C07D231/18 ,  C07D307/68 ,  C07D307/77 ,  C07D405/12 ,  C07D413/12

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）的化合物：其中：R 2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（-O），S（-O ）N 2，或NR 11，其中R 0,1选自H或任选取代的C 1-4烷基 ，或Y是-C（-O）NR N2 - ，其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基，其中如果两个C 6 芳基是苯环，两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5〜20 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1 -C 6烷基， 烷基; （ⅳ）四唑-5-基。

公开(公告)号：US20070135503A1

公开(公告)日：2007-06-14

申请号：US10576095

申请日：2004-10-15

申请人： David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark

发明人： David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark

IPC分类号： A61K31/41 ,  A61K31/34 ,  A61K31/405 ,  C07D307/02

CPC分类号： C07D307/68

摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.

摘要翻译： 式（I）化合物或其盐，溶剂合物和化学保护形式，其中R 2和R 5中的一个为：（i）H或任选地 取代的C 1-4烷基; 或（ii）任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1，m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3， SUP>是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5〜20 其中R 3，N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N， 1-4个C 1-4烷基; 或（iv）四唑-5-基。

公开(公告)号：US20060063792A1

公开(公告)日：2006-03-23

申请号：US11227685

申请日：2005-09-15

申请人： Roland Dolle ,  Bertrand Le Bourdonnec ,  Jonathan Sutton ,  Paul Eastwood ,  Ines Warner

发明人： Roland Dolle ,  Bertrand Le Bourdonnec ,  Jonathan Sutton ,  Paul Eastwood ,  Ines Warner

IPC分类号： A61K31/485 ,  C07D489/02

CPC分类号： C07D489/08 ,  C07D489/06

摘要： Novel 4,5-α epoxy-morphinan compounds are disclosed. Pharmaceutical compositions containing the 4,5-α epoxy-morphinan compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.

摘要翻译： 公开了新的4,5-α环氧吗啡喃化合物。 还公开了含有4,5-α环氧 - 吗啡喃化合物的药物组合物及其药物用途的方法。 所公开的化合物尤其可用作阿片受体的调节剂。

公开(公告)号：US20100232591A1

公开(公告)日：2010-09-16

申请号：US12382284

申请日：2009-03-12

申请人： Rodney Valentine ,  Laplie Anderson ,  Jonathan Sutton

发明人： Rodney Valentine ,  Laplie Anderson ,  Jonathan Sutton

IPC分类号： H04M3/42

CPC分类号： H04M3/493 ,  H04M3/42348 ,  H04M3/4931 ,  H04M2201/38 ,  H04M2242/15

摘要： An electronic telephone directory system is described. Each entry in the directory has summary information, category specific information, and associated categories. The system displays a different view of the category specific information depending on categories associated with an entry. For example, a restaurant may have a detailed view that shows its menu and specials whereas the detailed view for a taxi service shows the company's coverage area. The directory periodically updates using cellular networks but generally operates without an active network connection.

摘要翻译： 描述电子电话簿系统。 目录中的每个条目都有摘要信息，类别特定信息和关联的类别。 系统根据与条目关联的类别显示类别特定信息的不同视图。 例如，餐厅可能会有一个详细的视图，显示其菜单和特色，而出租车服务的详细视图显示公司的覆盖面积。 目录使用蜂窝网络定期更新，但通常在没有活动网络连接的情况下运行。

公开(公告)号：US20070207232A1

公开(公告)日：2007-09-06

申请号：US10596721

申请日：2004-12-14

申请人： Roy Nelson ,  William Coatesworth ,  John Walker ,  Jonathan Sutton ,  Richard Craggs

发明人： Roy Nelson ,  William Coatesworth ,  John Walker ,  Jonathan Sutton ,  Richard Craggs

IPC分类号： B29C44/58 ,  B29C45/58 ,  A23B4/16 ,  A23C3/037

CPC分类号： A23G1/208 ,  A23G1/56 ,  A23G3/02 ,  A23G3/0294 ,  A23G3/346 ,  A23G9/28 ,  A23G2220/02 ,  B05B12/087 ,  B05C5/0225 ,  B29C44/3492 ,  B29K2105/04 ,  B65B39/004

摘要： The invention is a depositing device (5) for depositing flowable food containing gas comprising a pressurized feed line conveying flowable food containing gas under pressure into the food; piston (60) means operatively connected to the feed line comprising a piston and a chamber (61); an outlet to deliver food at the atmospheric pressure into moulds (85). The device comprises a pressure retaining means (9) arranged to retain the product in the chamber at the same pressure as the line pressure and to deliver the product through the outlet as pressure in the chamber increases from the line pressure upon descent of the piston in the chamber.

摘要翻译： 本发明是一种用于沉积含有气体的可流动食品的沉积装置（5），包括一个加压进料管线，该压力进料管线将含有气体的可流动食品输送到食品中; 活塞（60）装置可操作地连接到包括活塞和腔室（61）的进料管线; 在大气压力下将食物送入模具（85）的出口。 该装置包括压力保持装置（9），该压力保持装置（9）被布置成在与管线压力相同的压力下将产品保持在腔室中，并且当该腔室中的压力从活塞下降时的管路压力增加时，将产品输送通过出口 房间。

公开(公告)号：US09400056B2

公开(公告)日：2016-07-26

申请号：US13255364

申请日：2010-02-24

申请人： John Howard Walker ,  John Michael Leadbeater ,  Jonathan Sutton

发明人： John Howard Walker ,  John Michael Leadbeater ,  Jonathan Sutton

IPC分类号： A23G3/02 ,  F16K1/08 ,  A23G1/00 ,  A23G3/34 ,  B05C5/02 ,  A21C5/00 ,  A23G3/20 ,  A21C11/16 ,  A23G1/20 ,  A21C9/08 ,  F16K1/04

CPC分类号： F16K1/08 ,  A21C5/006 ,  A21C9/08 ,  A21C11/16 ,  A23G1/0066 ,  A23G1/205 ,  A23G1/206 ,  A23G3/0027 ,  A23G3/0236 ,  A23G3/0252 ,  A23G3/0257 ,  A23G3/20 ,  A23G3/2023 ,  A23G3/203 ,  B05C5/0225 ,  F16K1/04

摘要： An apparatus for depositing a liquid, semi-liquid or semi-solid food product. The apparatus comprises a fixed volume chamber for receiving the food product under a positive pressure, the chamber being defined by chamber walls, one of the chamber walls being provided with an outlet orifice for depositing the food product, the outlet orifice being provided with a first sealing surface. The apparatus also comprises a valve spindle arranged for reciprocating movement within the chamber, the length direction of the valve spindle extending substantially perpendicular to the chamber wall in which the outlet orifice is provided, a first end of the valve spindle being provided with a second sealing surface. The second sealing surface of the valve spindle is arranged for abutting the first sealing surface of the outlet orifice to thereby close the outlet orifice.

摘要翻译： 一种用于沉积液体，半液体或半固体食品的设备。 该装置包括用于在正压力下接收食品的固定容积室，该室由室壁限定，其中一个室壁设置有用于沉积食品的出口孔，出口孔设置有第一 密封面。 所述设备还包括阀芯，所述阀芯被布置用于在所述腔室内往复运动，所述阀芯的长度方向基本上垂直于所述腔室壁延伸，所述腔室壁中设置有所述出口孔，所述阀芯的第一端设置有第二密封 表面。 阀芯的第二密封表面布置成邻接出口孔的第一密封表面，从而封闭出口孔。

公开(公告)号：US20120160160A1

公开(公告)日：2012-06-28

申请号：US13255364

申请日：2010-02-24

申请人： John Howard Walker ,  John Michael Leadbeater ,  Jonathan Sutton

发明人： John Howard Walker ,  John Michael Leadbeater ,  Jonathan Sutton

IPC分类号： A23G3/02 ,  B65B1/04

CPC分类号： F16K1/08 ,  A21C5/006 ,  A21C9/08 ,  A21C11/16 ,  A23G1/0066 ,  A23G1/205 ,  A23G1/206 ,  A23G3/0027 ,  A23G3/0236 ,  A23G3/0252 ,  A23G3/0257 ,  A23G3/20 ,  A23G3/2023 ,  A23G3/203 ,  B05C5/0225 ,  F16K1/04

摘要： An apparatus for depositing a liquid, semi-liquid or semi-solid food product. The apparatus comprises a fixed volume chamber for receiving the food product under a positive pressure, the chamber being defined by chamber walls, one of the chamber walls being provided with an outlet orifice for depositing the food product, the outlet orifice being provided with a first sealing surface. The apparatus also comprises a valve spindle arranged for reciprocating movement within the chamber, the length direction of the valve spindle extending substantially perpendicular to the chamber wall in which the outlet orifice is provided, a first end of the valve spindle being provided with a second sealing surface. The second sealing surface of the valve spindle is arranged for abutting the first sealing surface of the outlet orifice to thereby close the outlet orifice.

摘要翻译： 一种用于沉积液体，半液体或半固体食品的设备。 该装置包括用于在正压力下接收食品的固定容积室，该室由室壁限定，其中一个室壁设置有用于沉积食品的出口孔，出口孔设置有第一 密封面。 所述设备还包括阀芯，所述阀芯被布置用于在所述腔室内往复运动，所述阀芯的长度方向基本上垂直于设置有所述出口孔的室壁延伸，所述阀芯的第一端设有第二密封 表面。 阀芯的第二密封表面布置成邻接出口孔的第一密封表面，从而封闭出口孔。

公开(公告)号：US20070123575A1

公开(公告)日：2007-05-31

申请号：US11615024

申请日：2006-12-22

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

IPC分类号： A61K31/41 ,  A61K31/34 ,  C07D405/02

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): ; or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）的化合物：其中：R 2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（-O），S（-O ）N 2，或NR 11，其中R 0,1选自H或任选取代的C 1-4烷基 ，或Y是-C（-O）NR N2 - ，其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基，其中如果两个C 6 芳基是苯环，两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是：（i）羧基; （ii）式（II）的组： 或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20-20芳基或NR N 3， 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1-4烷基 ; （ⅳ）四唑-5-基。

公开(公告)号：US20060074923A1

公开(公告)日：2006-04-06

申请号：US10540256

申请日：2003-12-30

申请人： Andrew Gower ,  Martin Trimby ,  Jonathan Sutton

发明人： Andrew Gower ,  Martin Trimby ,  Jonathan Sutton

IPC分类号： G06F7/00

CPC分类号： G06F17/30265

摘要： A method to create within a computer system, an association between the appearance of a token and one or more stored files for the purpose of retrieving and presenting said one or more stored files, comprising the steps of: measuring said appearance of said token; creating a token identity from the obtained measurement; storing said token identity in an identity store; associating within said computer system, said stored file with said token identity; subsequently measuring said appearance of said token; creating a subsequent identity for said token using subsequent measurement data obtained from said subsequent measurement; searching in said identity store for a match with said subsequent identity; upon the location of a match, retrieving said one or more stored files; and presenting said retrieved file to a user.

摘要翻译： 一种在计算机系统内创建用于检索和呈现所述一个或多个存储的文件的令牌外观与一个或多个存储的文件之间的关联的方法，包括以下步骤：测量所述令牌的所述外观; 从获得的测量中创建令牌标识; 将所述令牌身份存储在身份存储中; 在所述计算机系统内关联所述存储的文件与所述令牌标识; 随后测量所述令牌的所述外观; 使用从所述后续测量获得的后续测量数据创建所述令牌的后续身份; 在所述身份存储中搜索与所述后续身份的匹配; 在匹配的位置上，检索所述一个或多个存储的文件; 并将所述检索的文件呈现给用户。

公开(公告)号：US20050256170A1

公开(公告)日：2005-11-17

申请号：US11055724

申请日：2005-02-11

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D213/81 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/02 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D213/81 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O., and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when RP3 is —Cm alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: —CO2H (carboxy); —CONH2; —CH2-OH; or tetrazol-5-yl.