公开(公告)号：US10427478B2

公开(公告)日：2019-10-01

申请号：US15628286

申请日：2017-06-20

申请人： Robert Coleman

发明人： Robert Coleman

IPC分类号： B60D1/02 ,  B60D1/06 ,  B60D1/07 ,  B60D1/14 ,  B60D1/00

摘要： A tow ball adaptor for coupling an implement hitch to a tow ball includes a plate. A first hole in the plate is complementary to and configured to insert a tow ball that is coupled to a vehicle. A coupler is coupled to the plate and configured to couple to the tow ball to retain the tow ball in the first hole. A cutout that extends into the plate is substantially complementary to and configured to insert an implement hitch. A plurality of third holes in the plate extends linearly between the first hole and the cutout. The third holes are complementary to and positioned to selectively align with a pair of orifices that is positioned singly in an upper and a lower tongue of the implement hitch. A hitch pin is inserted through the orifices and the third hole to couple the implement hitch to the plate.

公开(公告)号：US20180361808A1

公开(公告)日：2018-12-20

申请号：US15628286

申请日：2017-06-20

申请人： Robert Coleman

发明人： Robert Coleman

IPC分类号： B60D1/06 ,  B60D1/14

CPC分类号： B60D1/06 ,  B60D1/02 ,  B60D1/075 ,  B60D1/143 ,  B60D2001/008

摘要： A tow ball adaptor for coupling an implement hitch to a tow ball includes a plate. A first hole in the plate is complementary to and configured to insert a tow ball that is coupled to a vehicle. A coupler is coupled to the plate and configured to couple to the tow ball to retain the tow ball in the first hole. A cutout that extends into the plate is substantially complementary to and configured to insert an implement hitch. A plurality of third holes in the plate extends linearly between the first hole and the cutout. The third holes are complementary to and positioned to selectively align with a pair of orifices that is positioned singly in an upper and a lower tongue of the implement hitch. A hitch pin is inserted through the orifices and the third hole to couple the implement hitch to the plate.

公开(公告)号：US20150090750A1

公开(公告)日：2015-04-02

申请号：US14500391

申请日：2014-09-29

申请人： Robert Coleman

发明人： Robert Coleman

IPC分类号： F42B39/26

CPC分类号： F42B39/02 ,  A45F2005/008 ,  A45F2200/0591

摘要： Disclosed is a magazine holder for a firearm. The magazine holder includes a front segment, a middle segment, and a rear segment, wherein the segments are connected to form a unitary structure. The front segment and the rear segment are folded upwards to wrap around a forearm of a user. The middle segment is folded downward to create a slot to hold a magazine therebetween. The magazine holder mounts to the forearm of the user by means of a front and a rear adjustable strap, wherein the front adjustable strap is connected to the front segment and can wrap around the wrist of the user. The rear adjustment strap is connected to the rear segment and can wrap around the forearm of the user near the elbow. In one embodiment, the front adjustable strap may comprise hook and loop fasteners and the rear adjustable strap may comprise release buckles.

摘要翻译： 披露的是枪支的杂志架。 杂志架包括前段，中间段和后段，其中段被连接以形成整体结构。 前段和后段被向上折叠以围绕使用者的前臂。 中间部分向下折叠以形成一个狭槽，以便在其间夹住杂物。 杂志架通过前后可调节带子安装到使用者的前臂，其中前可调节带连接到前部段并且可以包裹在使用者的手腕上。 后调节带连接到后部段，并可以围绕肘部附近的使用者前臂缠绕。 在一个实施例中，前可调节带可以包括钩和环紧固件，并且后可调节带可以包括释放带扣。

公开(公告)号：US20110142602A1

公开(公告)日：2011-06-16

申请号：US12638186

申请日：2009-12-15

申请人： Mohammad Waseem ADHAMI ,  Stephen Bartlett ,  Robert Coleman ,  Kenneth Meiners

发明人： Mohammad Waseem ADHAMI ,  Stephen Bartlett ,  Robert Coleman ,  Kenneth Meiners

IPC分类号： F01D17/16

CPC分类号： F02C9/18 ,  F01D17/162 ,  F02C9/20 ,  F05D2260/80

摘要： Variable elements of a turbine engine such as variable inlet guide vanes, variable bleed valves and variable stator vanes can be adjusted to provide a desired level of power and/or efficiency for the turbine engine across a range of operating conditions. The variable element settings typically determined through experimentation when the engine is new. Unfortunately, over the life cycle of the turbine engine, as wear occurs, the original variable element settings may no longer provide a desired level of power and efficiency. To correct this problem, offsets to the original variable element settings are calculated based on observable operational conditions which provide a measure of the wear that has occurred. The offsets are applied to the original variable element settings to generate corrected variable element settings. These corrected variable element settings are then used to configure the turbine engine. The corrected variable element settings allow the turbine engine to continue to operate at a desired level of power and/or efficiency over the life of the turbine engine, despite any deterioration which may have occurred due to normal life cycle wear.

摘要翻译： 涡轮发动机的可变元件，例如可变入口导向叶片，可变放气阀和可变定子叶片可以被调节以在涡轮发动机的一系列操作条件下提供期望水平的功率和/或效率。 当发动机是新的时，通常通过实验确定可变元件设置。 不幸的是，在涡轮发动机的生命周期中，随着磨损发生，原始可变元件设置可能不再提供期望的功率和效率水平。 为了纠正这个问题，原始可变元件设置的偏移是基于可观测的操作条件计算的，这些操作条件提供了已经发生的磨损量度。 偏移量应用于原始可变元件设置以生成校正的可变元件设置。 然后将这些校正的可变元件设置用于配置涡轮发动机。 校正的可变元件设置允许涡轮发动机在涡轮发动机的使用寿命期间继续以期望的功率水平和/或效率运行，尽管由于正常的生命周期磨损而可能发生的任何劣化。

公开(公告)号：US20070219115A1

公开(公告)日：2007-09-20

申请号：US10578290

申请日：2004-12-02

申请人： Robert Coleman ,  Ingunn Holen ,  Helen Neville-Webbe ,  Catherine Evans

发明人： Robert Coleman ,  Ingunn Holen ,  Helen Neville-Webbe ,  Catherine Evans

IPC分类号： A61K31/675 ,  A61K31/16 ,  A61K31/21 ,  A61K38/16 ,  A61K31/4196 ,  A61K31/663

CPC分类号： A61K31/337 ,  A61K31/4196 ,  A61K31/663 ,  A61K2300/00

摘要： A method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a chemotherapeutic agent selected from the group consisting of: taxol, a derivative thereof and letrozole, followed sequentially by an effective amount of a bisphosphonate. The invention further provides a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonate followed sequentially by an effective amount of TRAIL.

摘要翻译： 一种治疗患有恶性疾病的患者的方法，包括向患者施用有效量的选自以下的化学治疗剂：紫杉醇，其衍生物和来曲唑，然后依次加入有效量的双膦酸盐。 本发明还提供了治疗患有恶性疾病的患者的方法，其包括向患者施用有效量的双膦酸盐，然后依次用有效量的TRAIL给药。

公开(公告)号：US5604177A

公开(公告)日：1997-02-18

申请号：US500391

申请日：1995-07-10

申请人： Alan Kinnersley ,  Robert Coleman ,  Edward Tolbert

发明人： Alan Kinnersley ,  Robert Coleman ,  Edward Tolbert

IPC分类号： A01N37/04 ,  A01N37/44 ,  C05F11/00 ,  C05G3/00

CPC分类号： C05G3/0064 ,  A01N37/44 ,  C05F11/00

摘要： A process for increasing plant growth and productivity comprising treating the roots, stems and/or foliage of the plant with .gamma.-aminobutyric acid and succinic acid as a readily metabolized source of carbon. The present invention also provides for a process for increasing plant growth and productivity comprising treating the roots of the plant with .gamma.-aminobutyric acid and succinic acid, and a process for increasing the rate of root formation in a plant comprising treating the roots, stems and foliage of the plant with .gamma.-aminobutyric acid and succinic acid. Further, plant growth is increased by application of mixtures of .gamma.-aminobutyric acid and synthetic succinic acid, in a suitable carrier to a plant.

摘要翻译： 一种用于增加植物生长和生产力的方法，包括用γ-氨基丁酸和琥珀酸处理植物的根，茎和/或叶子作为容易代谢的碳源。 本发明还提供了用于增加植物生长和生产率的方法，包括用γ-氨基丁酸和琥珀酸处理植物的根，以及用于增加植物中根形成速率的方法，包括处理根，茎和 植物的叶子与γ-氨基丁酸和琥珀酸。 此外，通过将γ-氨基丁酸和合成琥珀酸的混合物在合适的载体中施用于植物来增加植物生长。

公开(公告)号：US1090382A

公开(公告)日：1914-03-17

申请号：US1911661881

申请日：1911-11-23

申请人： ROBERT COLEMAN ,  F M MCAULIFFE ,  BYRNES JOHN F

发明人： BYRNES JOHN F

CPC分类号： G07B13/005

公开(公告)号：US20070123575A1

公开(公告)日：2007-05-31

申请号：US11615024

申请日：2006-12-22

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Christopher Newton

IPC分类号： A61K31/41 ,  A61K31/34 ,  C07D405/02

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): ; or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）的化合物：其中：R 2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（-O），S（-O ）N 2，或NR 11，其中R 0,1选自H或任选取代的C 1-4烷基 ，或Y是-C（-O）NR N2 - ，其中R N2选自H和任选取代的C 1-7 - 烷基或C 5-20-20芳基; R 3是与另外任选取代的C 6 -C 6芳基连接的任选取代的C 6-14芳基，其中如果两个C 6 芳基是苯环，两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C 1-3-3亚烷基; 和R 5是：（i）羧基; （ii）式（II）的组： 或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20-20芳基或NR N 3， 其中R“N 3”和“R”N 4“独立地选自任选取代的C 1-4烷基 ; （ⅳ）四唑-5-基。

公开(公告)号：US20070020181A1

公开(公告)日：2007-01-25

申请号：US11349731

申请日：2006-02-07

申请人： Jerome Workman ,  Christopher Lambert ,  Robert Coleman

发明人： Jerome Workman ,  Christopher Lambert ,  Robert Coleman

IPC分类号： A61K49/00 ,  C12Q1/26

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/1455 ,  A61B5/413 ,  A61B5/415 ,  A61B5/418 ,  A61K49/0041 ,  A61K49/0052 ,  Y10T436/144444

摘要： This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.

摘要翻译： 本发明提供用于测定生物样品中的一种或多种代谢物或分析物的浓度的装置，组合物和方法，包括细胞，组织，器官，生物和生物流体。 特别地，本发明提供了用于基于在皮肤中发现的一种或多种生物活性分子的体内测量来确定体内血糖浓度水平的几种非侵入性技术的材料，装置和方法。

公开(公告)号：US20050256170A1

公开(公告)日：2005-11-17

申请号：US11055724

申请日：2005-02-11

申请人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

发明人： Alexander Oxford ,  Richard Davis ,  Robert Coleman ,  Kenneth Clark ,  David Clark ,  Neil Harris ,  Garry Fenton ,  George Hynd ,  Keith Stuttle ,  Jonathan Sutton ,  Mark Ashton ,  Edward Boyd ,  Shirley Brunton

IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D213/81 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/02 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D213/81 ,  C07C233/75 ,  C07C233/81 ,  C07C235/84 ,  C07D233/90 ,  C07D257/04 ,  C07D277/24 ,  C07D277/26 ,  C07D277/56 ,  C07D307/46 ,  C07D307/68 ,  C07D307/91 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisiting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O., and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN′ is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally when RP3 is —Cm alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optionally substituted C1-4 alkyl; R2 is either: —CO2H (carboxy); —CONH2; —CH2-OH; or tetrazol-5-yl.