Abstract:
The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
Abstract:
An acoustic device and method of making said acoustic device. The acoustic device comprises a diaphragm having resonant bending wave modes in the operating frequency range, and a plurality of electromechanical transducers coupled to the diaphragm. The positioning and mechanical impedance of the transducers are such that at least a selected number of the resonant bending wave modes are balanced so that the net transverse modal velocity over the area of the diaphragm tends to zero with the balancing of the resonant bending wave modes being achieved substantially by the positioning and mechanical impedance of the transducers. The parameters of the diaphragm may be such that there are a plurality of nodal grouped locations at or around which the nodal lines of a selected number of resonant modes are clustered. Each transducer may be mounted at one of the plurality of nodal grouped locations.
Abstract:
A transducer (14) for producing a force which excites an acoustic radiator, e.g. a panel (12) to produce an acoustic output. The transducer (14) has an intended operative frequency range and comprises a resonant element which has a distribution of modes and which is modal in the operative frequency range. Parameters of the transducer (14) may be adjusted to improve the modality of the resonant element. A loudspeaker (10) or a microphone may incorporate the transducer.
Abstract:
Acoustic device including a member extending transversely of its thickness and capable of sustaining bending waves at least over an intendedly consequentially acoustically active area of the transverse extent of said member, the member having, by reason of orderly design methodology disclosed and claimed, a distribution of resonant modes of its natural bending wave vibration at least over said area that is dependent on values of particular parameters of said members, including geometrical configuration and directional bending stiffness(es), which values have been selected to predetermine said distribution of natural resonant modes being consonant with required achievable acoustic action of said member for operation of said device over a desired operative acoustic frequency range.
Abstract:
A transducer (14) for producing a force which excites an acoustic radiator, e.g. a panel (12) to produce an acoustic output. The transducer (14) has an intended operative frequency range and comprises a resonant element which has a distribution of modes and which is modal in the operative frequency range. Parameters of the transducer (14) may be adjusted to improve the modality of the resonant element. A loudspeaker (10) or a microphone may incorporate the transducer.
Abstract:
A loudspeaker comprising a phase uncorrelated diffuse sound source and a duct or wave guide coupled to the sound source to direct acoustic energy from the source, the duct or wave guide having a substantially parallel section extending from the vicinity of the sound source and a termination positioned remotely from the panel.
Abstract:
Acoustic device including a member extending transversely of its thickness and capable of sustaining bending waves at least over an intendedly consequentially acoustically active area of the transverse extent of said member, the member having, by reason of orderly design methodology disclosed and claimed, a distribution of resonant modes of its natural bending wave vibration at least over said area that is dependent on values of particular parameters of said members, including geometrical configuration and directional bending stiffness(es), which values have been selected to predetermine said distribution of natural resonant modes being consonant with required achievable acoustic action of said member for operation of said device over a desired operative acoustic frequency range.
Abstract:
Acoustic device including a member extending transversely of its thickness and capable of sustaining bending waves at least over an intendedly consequentially acoustically active area of the transverse extent of said member, the member having, by reason of orderly design methodology disclosed and claimed, a distribution of resonant modes of its natural bending wave vibration at least over said area that is dependent on values of particular parameters of said members, including geometrical configuration and directional bending stiffness(es), which values have been selected to predetermine said distribution of natural resonant modes being consonant with required achievable acoustic action of said member for operation of said device over a desired operative acoustic frequency range.
Abstract:
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
Abstract translation:式(I)化合物或其盐,溶剂合物和化学保护形式,其中R 2和R 5中的一个为:(i)H或任选地 取代的C 1-4烷基; 或(ii)任选取代的C 5-7芳基; R 2和R 5中的另一个是另一个基团; m和n可以是0或1,m + n = 1或2 R N是H或任选取代的C 1-4烷基R 3, SUP>是:(i)羧基; (ii)式(II)的基团:(iii)式(III)的基团:其中R是任选取代的C 1-7烷基,C 5〜20 其中R 3,N 3和R 4各自独立地选自任选取代的C 1 -C 6芳基或NR N 3 N, 1-4个C 1-4烷基; 或(iv)四唑-5-基。
Abstract:
A loudspeaker includes an assembly of at least two bending wave panel-form acoustic members each having a set of modes which are distributed in frequency. The parameters of at least two of the acoustic members are selected so that the modal distributions of each acoustic member are substantially different. The arrangement is such that the modal distributions of the assembly of acoustic members are interleaved constructively in frequency. A transducer applies bending wave energy to the acoustic members to cause them to resonate to produce an acoustic output. A method of making such a loudspeaker is also provided.