- 专利标题： Use of microparticles combined with submicron oil-in-water emulsions
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申请号： US11053290申请日： 2005-02-08
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公开(公告)号： US20050136073A1公开(公告)日： 2005-06-23
- 发明人: Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
- 申请人： Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
- 申请人地址： US CA Emeryville
- 专利权人： Chiron Corporation
- 当前专利权人： Chiron Corporation
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/107 ; A61K9/16 ; A61K39/21 ; A61K39/29 ; A61K39/39 ; A61P37/04 ; A61K39/12 ; A61K9/50
摘要：
Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
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