发明申请
- 专利标题: Fibrosis inhibitor
- 专利标题(中): 纤维化抑制剂
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申请号: US10502933申请日: 2003-01-28
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公开(公告)号: US20050227978A1公开(公告)日: 2005-10-13
- 发明人: Teruhisa Tokunaga , Willian Hume , Makoto Kitoh , Ryu Nagata , Michiko Kishino , Tsutomu Nakagawa , Jun Nagamine , Mutsuo Taiji
- 申请人: Teruhisa Tokunaga , Willian Hume , Makoto Kitoh , Ryu Nagata , Michiko Kishino , Tsutomu Nakagawa , Jun Nagamine , Mutsuo Taiji
- 申请人地址: JP Osaka
- 专利权人: Sumitomo Pharmaceuticals Co., Ltd.
- 当前专利权人: Sumitomo Pharmaceuticals Co., Ltd.
- 当前专利权人地址: JP Osaka
- 优先权: JP2002-021056 20020130
- 国际申请: PCT/JP03/00811 WO 20030128
- 主分类号: A61K31/381
- IPC分类号: A61K31/381 ; A61K31/40 ; A61K31/4025 ; A61K31/404 ; A61K31/41 ; A61K31/415 ; A61K31/4155 ; A61K31/4174 ; A61K31/425 ; A61K31/427 ; A61K31/428 ; A61K31/4439 ; A61K31/4709 ; A61K31/496 ; A61K31/498 ; A61K31/4985 ; A61K31/5377 ; A61P11/00 ; A61P13/12 ; A61P17/00 ; A61P43/00 ; C07D207/32 ; C07D207/333 ; C07D233/64 ; C07D401/06 ; A61K31/401 ; A61K31/4164
摘要:
Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.
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