发明申请
US20050287121A1 Methods, compositions and compound assays for inhibiting amyloid-beta protein production
审中-公开
用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法
- 专利标题： Methods, compositions and compound assays for inhibiting amyloid-beta protein production
- 专利标题（中）： 用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法
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申请号： US11127622申请日： 2005-05-12
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公开(公告)号： US20050287121A1公开(公告)日： 2005-12-29
- 发明人: Pascal Merchiers , Marcel Hoffmann , Koenraad Spittaels , Wendy Laenen
- 申请人： Pascal Merchiers , Marcel Hoffmann , Koenraad Spittaels , Wendy Laenen
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/00 ; C12Q1/25 ; C12Q1/48 ; C12Q1/68 ; G01N20060101 ; G01N33/53 ; G01N33/567 ; G01N33/68 ; G01N33/74
摘要：
A method for identifying compounds that inhibit aberrant amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a LIGASE polypeptide, or fragment thereof, and measuring a compound-LIGASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of LIGASE DNA expression agents or LIGASE agonists, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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