- 专利标题： Novel antigen constructs useful in the detection and differentiation of antibodies to HIV
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申请号： US11008351申请日： 2004-12-09
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公开(公告)号： US20060153866A1公开(公告)日： 2006-07-13
- 发明人: John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
- 申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07K14/16
摘要：
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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