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1.发明授权Antigen constructs useful in the detection and differentiation of antibodies to HIV 有权用于HIV抗体检测和分化的抗原构建体公开(公告)号：US07619061B2
公开(公告)日：2009-11-17
申请号：US11008351
申请日：2004-12-09
申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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2.发明申请公开(公告)号：US20080090226A1
公开(公告)日：2008-04-17
申请号：US11954356
申请日：2007-12-12
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Shushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Shushil Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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公开(公告)号：US09150834B2
公开(公告)日：2015-10-06
申请号：US13028816
申请日：2011-02-16
IPC分类号： C12N15/49 , C12N7/00 , C07K14/16 , C07K14/005 , C12Q1/70
CPC分类号： C12N7/00 , C07K14/005 , C07K14/16 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703
摘要： The present invention relates to Human Immunodeficiency Virus-1 (HIV-1) Group P of the strain designated 06CMU14788 and fragments thereof, primers which are derived from HIV-1 Group P, immunogenic regions thereof, immunoassays and nucleic acid based assays for the detection of Human Immunodeficiency Virus (HIV) that employ said HIV-1 Group P or fragments thereof and therapeutic compositions containing said HIV-1 Group P or fragments thereof.
摘要翻译： 本发明涉及称为06CMU14788的菌株的人类免疫缺陷病毒-1（HIV-1）组P及其片段，源自HIV-1组P的引物，其免疫原性区，用于检测的免疫测定和基于核酸的测定 使用所述HIV-1组P或其片段的人类免疫缺陷病毒（HIV）和含有所述HIV-1组P或其片段的治疗组合物。
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4.发明申请NOVEL ANTIGEN CONSTRUCTS USEFUL IN THE DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV 有权用于艾滋病毒抗体检测和鉴别的新型抗原结构公开(公告)号：US20100035237A1
公开(公告)日：2010-02-11
申请号：US12574407
申请日：2009-10-06
申请人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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5.发明申请公开(公告)号：US20060153866A1
公开(公告)日：2006-07-13
申请号：US11008351
申请日：2004-12-09
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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公开(公告)号：US5667992A
公开(公告)日：1997-09-16
申请号：US453552
申请日：1995-05-30
申请人： James M. Casey , Suzanne L. Bode , Billy J. Zeck , Julie Yamaguchi , Donald E. Frail , Suresh M. Desai , Sushil G. Devare
发明人： James M. Casey , Suzanne L. Bode , Billy J. Zeck , Julie Yamaguchi , Donald E. Frail , Suresh M. Desai , Sushil G. Devare
IPC分类号： C12N15/09 , A61K38/00 , C07K14/18 , C07K16/00 , C07K16/10 , C07K19/00 , C12P21/02 , C12P21/08 , C12Q1/70 , C12R1/91 , C12P21/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Mammalian expression systems for the production of HCV proteins. Such expression systems provide high yields of HCV proteins, and enable the development of diagnostic and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.
摘要翻译： 用于生产HCV蛋白的哺乳动物表达系统。 这种表达系统提供高产量的HCV蛋白质，并且能够开发含有糖基化结构抗原的诊断和治疗试剂，并且还允许分离HCV病原体。
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公开(公告)号：US5610009A
公开(公告)日：1997-03-11
申请号：US188281
申请日：1994-01-28
IPC分类号： G01N33/576 , A61K39/00 , A61K39/29 , A61K39/395 , A61P31/12 , C07H21/04 , C07K14/18 , C07K14/47 , C07K16/08 , C07K19/00 , C12N15/09 , C12P21/02 , C12Q1/70
CPC分类号： C07K14/005 , C07K14/4711 , A61K39/00 , C07K2319/00 , C12N2770/24222 , Y10S436/82
摘要： Mammalian expression systems for the production of HCV E1-E2 fusion proteins. Such expression systems provide high yields of HCV proteins extracelluarly, and enable the development of diagnostic, vaccine and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.
摘要翻译： 用于生产HCV E1-E2融合蛋白的哺乳动物表达系统。 这种表达系统提供高产量的HCV蛋白质，并且能够开发含有糖基化结构抗原的诊断，疫苗和治疗试剂，并且还允许HCV病原体的分离。
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公开(公告)号：US20110281258A1
公开(公告)日：2011-11-17
申请号：US13028816
申请日：2011-02-16
IPC分类号： C12Q1/70 , C07K16/10 , C07K14/155 , G01N33/566 , C07H21/04
CPC分类号： C12N7/00 , C07K14/005 , C07K14/16 , C12N2740/15022 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703
摘要： The present invention relates to Human Immunodeficiency Virus-1 (HIV-1) Group P of the strain designated 06CMU14788 and fragments thereof, primers which are derived from HIV-1 Group P, immunogenic regions thereof, immunoassays and nucleic acid based assays for the detection of Human Immunodeficiency Virus (HIV) that employ said HIV-1 Group P or fragments thereof and therapeutic compositions containing said HIV-1 Group P or fragments thereof.
摘要翻译： 本发明涉及称为06CMU14788的菌株的人类免疫缺陷病毒-1（HIV-1）组P及其片段，源自HIV-1组P的引物，其免疫原性区，用于检测的免疫测定和基于核酸的测定 使用所述HIV-1组P或其片段的人类免疫缺陷病毒（HIV）和含有所述HIV-1组P或其片段的治疗组合物。
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9.发明申请NOVEL ANTIGEN CONSTRUCTS USEFUL IN THE DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV 失效用于艾滋病毒抗体检测和鉴别的新型抗原结构公开(公告)号：US20110091868A1
公开(公告)日：2011-04-21
申请号：US12973384
申请日：2010-12-20
申请人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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公开(公告)号：US07615614B2
公开(公告)日：2009-11-10
申请号：US11954356
申请日：2007-12-12
申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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