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1.发明申请公开(公告)号：US20060153866A1
公开(公告)日：2006-07-13
申请号：US11008351
申请日：2004-12-09
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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2.发明申请Novel Antigen Constructs Useful In the Detection and Differentiation of Antibodies to HIV 有权用于HIV抗体检测和分化的新型抗原构建体公开(公告)号：US20080090994A1
公开(公告)日：2008-04-17
申请号：US11954351
申请日：2007-12-12
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Sushil Devare
IPC分类号： C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译： 要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体 多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。 还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。
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3.发明申请公开(公告)号：US20080090226A1
公开(公告)日：2008-04-17
申请号：US11954356
申请日：2007-12-12
申请人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Shushil Devare
发明人： John Hackett , Julie Yamaguchi , Alan Golden , Catherine Brennan , Robert Hickman , Shushil Devare
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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4.发明申请INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS 审中-公开使用对称和非对称二苯醚类尿素抑制P38激酶公开(公告)号：US20090093526A1
公开(公告)日：2009-04-09
申请号：US11932397
申请日：2007-10-31
申请人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人： Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号： A61K31/40 , A61K31/44 , C07D207/36 , C07D213/04 , A61P19/02
CPC分类号： A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途，以及用于这种治疗的药物组合物。
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5.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权用于治疗与促血细胞生成相关的高血压疾病和疾病的吡咯烷酮衍生物公开(公告)号：US20100075958A1
公开(公告)日：2010-03-25
申请号：US12506033
申请日：2009-07-20
申请人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
发明人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
IPC分类号： A61K31/53 , C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及吡咯并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性病症和疾病的用途。
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6.发明申请Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders 失效用于治疗高增殖性疾病的取代的四氢苯并噻吩并嘧啶胺化合物公开(公告)号：US20060293322A1
公开(公告)日：2006-12-28
申请号：US10557090
申请日：2004-07-23
申请人： Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
发明人： Chengzhi Zhang , Gaetan Ladouceur , Catherine Brennan , Brent Chandler , Julie Dizon , Karl Miranda , Dongping Fan , Qingming Zhu , Sharad Verma , Jacques Dumas
IPC分类号： A61K31/5377 , A61K31/519 , C07D498/02
CPC分类号： C07D495/04 , C07D498/02
摘要： The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译： 本发明涉及式（I）化合物及其在治疗高增殖性疾病中的用途。
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7.发明授权Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权可用于治疗高增殖性疾病和与血管发生相关的疾病的吡咯嗪衍生物公开(公告)号：US08338595B2
公开(公告)日：2012-12-25
申请号：US12506033
申请日：2009-07-20
申请人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin D. Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
发明人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin D. Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及吡咯并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性病症和疾病的用途。
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8.发明申请公开(公告)号：US20090023753A1
公开(公告)日：2009-01-22
申请号：US11885104
申请日：2006-02-24
申请人： Chih-Yuan Chuang , Philip Wickens , Zhengiu Hong , Catherine Brennan , Julie A. Dixon , Harold C.E. Kluender , Charles Kreiman , Ellalahewage Kumarasinghe
发明人： Chih-Yuan Chuang , Philip Wickens , Zhengiu Hong , Catherine Brennan , Julie A. Dixon , Harold C.E. Kluender , Charles Kreiman , Ellalahewage Kumarasinghe
IPC分类号： A61K31/496 , A61P35/00 , C07D417/12 , A61K31/4535 , C07D403/06
CPC分类号： C07D417/12 , C07D417/14
摘要： This invention relates to novel 1,3-thiazole-5-carboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.
摘要翻译： 本发明涉及新的1,3-噻唑-5-甲酰胺化合物，含有这些化合物的药物组合物，以及这些化合物或组合物作为癌症化学治疗剂的用途。
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9.发明申请Pyrrolotriazine Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的吡咯嗪衍生物公开(公告)号：US20070208013A1
公开(公告)日：2007-09-06
申请号：US11596913
申请日：2005-06-03
申请人： Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
发明人： Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/53 , C07D487/04
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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10.发明授权Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权可用于治疗高增殖性疾病和与血管发生相关的疾病的吡咯嗪衍生物公开(公告)号：US07563791B2
公开(公告)日：2009-07-21
申请号：US11596913
申请日：2005-06-03
申请人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
发明人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61K35/00
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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