发明申请
- 专利标题: Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
- 专利标题(中): 非咪唑烷基胺作为组胺H3受体配体及其治疗应用
-
申请号: US11478682申请日: 2006-07-03
-
公开(公告)号: US20060247223A1公开(公告)日: 2006-11-02
- 发明人: Jean-Charles Schwartz , Jean-Michel Arrang , Monique Garbarg , Jeanne-Marie Lecomte , Xavier Ligneau , Walter Schunack , Holger Stark , Charon Ganellin , Fabien Leurquin , Sigurd Elz
- 申请人: Jean-Charles Schwartz , Jean-Michel Arrang , Monique Garbarg , Jeanne-Marie Lecomte , Xavier Ligneau , Walter Schunack , Holger Stark , Charon Ganellin , Fabien Leurquin , Sigurd Elz
- 优先权: EP98401944.8 19980729; EP98403351.4 19981231
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K31/445 ; A61K31/40 ; A61K31/397 ; A61K31/396
摘要:
Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.