发明申请
- 专利标题: Pyridin-2-one compounds useful as inhibitors of thrombin
- 专利标题(中): 可用作凝血酶抑制剂的吡啶-2-酮化合物
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申请号: US10597720申请日: 2005-02-02
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公开(公告)号: US20070161643A1公开(公告)日: 2007-07-12
- 发明人: Malken Bayrakdarian , Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Ingemar Nilsson , Mats Nagard , Daniel Simard , Eric Therrien
- 申请人: Malken Bayrakdarian , Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Ingemar Nilsson , Mats Nagard , Daniel Simard , Eric Therrien
- 优先权: SE0401658-0 20040624; SE0400254-9 20040206
- 国际申请: PCT/SE05/00124 WO 20050202
- 主分类号: A61K31/513
- IPC分类号: A61K31/513 ; C07D487/02
摘要:
There is provided a compound of formula I wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).
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