发明申请
US20070161643A1 Pyridin-2-one compounds useful as inhibitors of thrombin 审中-公开
可用作凝血酶抑制剂的吡啶-2-酮化合物

Pyridin-2-one compounds useful as inhibitors of thrombin
摘要:
There is provided a compound of formula I wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).
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