Invention Application
- Patent Title: Tie-2 Modulators and Methods of Use
- Patent Title (中): Tie-2调制器和使用方法
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Application No.: US10549300Application Date: 2004-03-19
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Publication No.: US20070275952A1Publication Date: 2007-11-29
- Inventor: Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
- Applicant: Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
- Applicant Address: US CA South San Francisco 94083-0511
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco 94083-0511
- International Application: PCT/US04/08579 WO 20040319
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/44 ; A61K31/445 ; A61K31/497 ; A61K31/535 ; A61K31/551 ; A61P35/00 ; C07D243/08 ; C07D285/10 ; C07D401/14 ; C07D413/00 ; C07D417/02 ; C12N5/00 ; C12Q1/00
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Public/Granted literature
- US08013156B2 Tie-2 modulators and methods of use Public/Granted day:2011-09-06
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