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公开(公告)号：US20070275952A1
公开(公告)日：2007-11-29
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
发明人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
IPC分类号： A61K31/41 , A61K31/44 , A61K31/445 , A61K31/497 , A61K31/535 , A61K31/551 , A61P35/00 , C07D243/08 , C07D285/10 , C07D401/14 , C07D413/00 , C07D417/02 , C12N5/00 , C12Q1/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20070244116A1
公开(公告)日：2007-10-18
申请号：US11753503
申请日：2007-05-24
申请人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/47 , A61K31/16 , A61K31/517 , C07C229/40 , C07D215/22 , C07D239/94 , C07D413/12 , C07D239/88 , C07C233/59 , A61K31/5355 , A61K31/196
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070054928A1
公开(公告)日：2007-03-08
申请号：US11586751
申请日：2006-10-26
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉 含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070208166A1
公开(公告)日：2007-09-06
申请号：US10576932
申请日：2004-10-22
申请人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
发明人： Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
IPC分类号： C07D471/02
CPC分类号： C07C237/22 , C07C275/16 , C07C275/34 , C07C2602/10 , C07D207/16 , C07D209/20 , C07D209/42 , C07D209/44 , C07D213/56 , C07D213/75 , C07D215/48 , C07D215/54 , C07D217/06 , C07D217/22 , C07D233/56 , C07D233/58 , C07D263/32 , C07D277/46 , C07D277/66 , C07D277/82 , C07D295/155 , C07D295/185 , C07D319/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译： 本发明提供了用于抑制激酶的化合物和方法，例如TAO族的那些，更具体地是KIAA1361，TAO和JIK激酶。 本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节与上述细胞活性变化相关的激酶受体信号转导途径，本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法 。
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公开(公告)号：US20060199820A1
公开(公告)日：2006-09-07
申请号：US10518110
申请日：2003-06-11
申请人： Lynne Bannen , Erick Co , Vasu Jammalamadaka , John Nuss , Moon Hwan Kim , Donna Le , Amy Lew , Morrison Mac , Shumeye Mamo , Richard Khoury , Zhaoyang Wen , Wei Xu
发明人： Lynne Bannen , Erick Co , Vasu Jammalamadaka , John Nuss , Moon Hwan Kim , Donna Le , Amy Lew , Morrison Mac , Shumeye Mamo , Richard Khoury , Zhaoyang Wen , Wei Xu
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/495 , C07D413/02 , C07D403/02
CPC分类号： C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要翻译： 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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公开(公告)号：US08013156B2
公开(公告)日：2011-09-06
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
发明人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4425 , A61K31/495 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20050227973A1
公开(公告)日：2005-10-13
申请号：US10498338
申请日：2002-12-13
申请人： S. Brown , Lynne Canne-Bannen , Erick Co , Vasu Jammalamadaka , Rickard Khoury , Moon Kim , Donna Le , Amy Tsuhako , Morrison Mac , Shumeye Mamo , John Nuss , Michael Prisbylla , Wei Xu
发明人： S. Brown , Lynne Canne-Bannen , Erick Co , Vasu Jammalamadaka , Rickard Khoury , Moon Kim , Donna Le , Amy Tsuhako , Morrison Mac , Shumeye Mamo , John Nuss , Michael Prisbylla , Wei Xu
IPC分类号： A61K31/40 , A61K31/18 , A61K31/277 , A61K31/405 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/445 , A61K31/4462 , A61K31/4465 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C303/02 , C07C303/40 , C07C309/87 , C07C311/29 , C07D207/09 , C07D211/34 , C07D213/56 , C07D213/65 , C07D213/70 , C07D233/48 , C07D233/54 , C07D295/13 , C07D295/15 , C07D295/185 , C07D295/215 , C07D311/70 , C07D409/04
CPC分类号： C07D409/04 , C07C311/29 , C07C2601/14 , C07D207/09 , C07D211/34 , C07D213/56 , C07D213/65 , C07D213/70 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/15 , C07D295/185 , C07D295/215 , C07D311/70
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.
摘要翻译： 本发明提供了可用于抑制ADAM-10蛋白质的化合物。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。 本发明还提供从其制备双芳基醚磺酰氯和ADAM-10调节剂的方法。
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公开(公告)号：US20060122171A1
公开(公告)日：2006-06-08
申请号：US10533555
申请日：2003-11-14
申请人： Wei Xu , Lynne Canne Bannen , Samuel Brown , Erick Co , John Nuss , Moon Kim , Rhett Klein , Donna Lee , Amy Tsuhako , Morrison Mac , Jason Parks , Zhaoyang Wen , Wei Cheng
发明人： Wei Xu , Lynne Canne Bannen , Samuel Brown , Erick Co , John Nuss , Moon Kim , Rhett Klein , Donna Lee , Amy Tsuhako , Morrison Mac , Jason Parks , Zhaoyang Wen , Wei Cheng
IPC分类号： A61K31/55 , A61K31/454 , C07D403/14
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D451/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是VEGF受体2（Flk-1 / KDR），FGFR1和PDGFR（α和β）的信号转导途径的羟吲哚衍生物，其与细胞的变化相关 如上所述的活性，含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。
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公开(公告)号：US20070208020A1
公开(公告)日：2007-09-06
申请号：US10576653
申请日：2004-10-22
申请人： Wei Cheng , Erick Co , Moon Kim , Rhett Klein , Donna Le , Amy Suhako , John Nuss , Wei Xu
发明人： Wei Cheng , Erick Co , Moon Kim , Rhett Klein , Donna Le , Amy Suhako , John Nuss , Wei Xu
IPC分类号： A61K31/5377 , A61K31/53 , A61K31/513 , C07D413/02 , C07D403/02
CPC分类号： C07D239/58 , C07D213/85 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D417/12 , C07D487/04 , C07D491/04
摘要： The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
摘要翻译： 本发明提供用于抑制激酶，更特别是p70S6激酶的化合物和方法。 本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移，化学侵袭和代谢的化合物。 本发明的化合物抑制，调节和/或调节与上述细胞活性变化相关的激酶受体信号转导途径，本发明包括含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法 。
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公开(公告)号：US20100105953A1
公开(公告)日：2010-04-29
申请号：US12605118
申请日：2009-10-23
申请人： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
发明人： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
IPC分类号： C07C315/00
CPC分类号： C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要翻译： 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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