Invention Application
US20080124328A1 Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
有权
中和肉毒杆菌神经毒素的治疗性单克隆抗体
- Patent Title: Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
- Patent Title (中): 中和肉毒杆菌神经毒素的治疗性单克隆抗体
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Application No.: US11342271Application Date: 2006-01-26
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Publication No.: US20080124328A1Publication Date: 2008-05-29
- Inventor: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelos Garcia
- Applicant: James D. Marks , Peter Amersdorfer , Isin Geren , Jianlong Lou , Ali Razai , Maria Consuelos Garcia
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Main IPC: A61K39/40
- IPC: A61K39/40 ; A61K39/395 ; A61P43/00 ; C07H19/00 ; C07K16/00 ; C12N1/00 ; C12N5/00
Abstract:
This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
Public/Granted literature
- US07700738B2 Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins Public/Granted day:2010-04-20
Information query
