发明申请
- 专利标题： In Vivo Incorporation of Alkynyl Amino Acids into Proteins in Eubacteria
- 专利标题（中）： 体内纳入炔基氨基酸到细菌中的蛋白质
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申请号： US11663513申请日： 2005-09-20
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公开(公告)号： US20080220472A1公开(公告)日： 2008-09-11
- 发明人: Alexander Deiters , Peter G. Schultz
- 申请人： Alexander Deiters , Peter G. Schultz
- 申请人地址： US CA La Jolla
- 专利权人： THE SCRIPPS RESEARCH INSTITUTE
- 当前专利权人： THE SCRIPPS RESEARCH INSTITUTE
- 当前专利权人地址： US CA La Jolla
- 国际申请： PCT/US05/33784 WO 20050920
- 主分类号： C12P21/04
- IPC分类号： C12P21/04 ; C12N1/20 ; C12N9/00 ; C12N15/11 ; C12N15/00
摘要：
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthoghonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing alkynyl amino acids, and cellular translation systems.
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